INT207212

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
brain 1
Creb1 (Mus musculus)
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 19 99.00 Very High Very High Very High
antidepressant 32 89.68 High High
Dopamine 1 74.64 Quite High
depression 10 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 98.48 Very High Very High Very High
Stress 69 97.56 Very High Very High Very High
Shock 2 91.04 High High
Targeted Disruption 26 50.00 Quite Low
Depressive Disorder 1 41.20 Quite Low
Depression 14 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Affective Disorder 3 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, changes in the transcriptional activity of CREB and of its gene product BDNF depend not only on the brain region but also on the type of stress and its duration.
CREB Regulation (changes) of BDNF in brain associated with stress
1) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.92 Pain Relevance 0.32

General Comments

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