INT20722

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.43
Pain Relevance 2.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACOT1) lipid metabolic process (ACOT1) cytoplasm (ACOT1)
Anatomy Link Frequency
blood 2
neuronal 2
vessels 2
ACOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 99.68 Very High Very High Very High
antagonist 2 96.66 Very High Very High Very High
Opioid 4 96.42 Very High Very High Very High
conotoxin 6 92.24 High High
nociceptor 3 92.16 High High
Pain 63 89.72 High High
Inflammation 3 89.00 High High
Action potential 8 87.00 High High
algil 3 86.84 High High
Morphine 3 86.28 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 30 90.40 High High
Pain 73 89.72 High High
INFLAMMATION 2 89.00 High High
Stress 4 88.48 High High
Cancer 2 75.96 Quite High
Paralysis 15 75.52 Quite High
Targeted Disruption 15 75.44 Quite High
Helminth Infection 22 67.20 Quite High
Neurogenic Inflammation 1 58.76 Quite High
Increased Venous Pressure Under Development 1 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The finding that high concentrations of synthetic opioids or opioid antagonists were required to inhibit output suggests that they may not be acting specifically, and provides no evidence for the hypothesis that endogenous opioids play a role in control of ACh release into fetal vessels of human placentae.
Regulation (control) of Localization (release) of ACh in vessels associated with antagonist, endogenous opioid and opioid
1) Confidence 0.27 Published 1989 Journal Placenta Section Abstract Doc Link 2674931 Disease Relevance 0 Pain Relevance 1.01
In addition, the modulation of NE release by adrenoceptor ligands displayed the appropriate pharmacology of alpha-2 autoreceptors; ACh release was modulated by muscarinic ligands.
Regulation (modulated) of Localization (release) of ACh
2) Confidence 0.21 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2156061 Disease Relevance 0.08 Pain Relevance 0.32
The effects of drugs on NE and ACh release were not age-related.
Regulation (effects) of Localization (release) of ACh
3) Confidence 0.19 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2156061 Disease Relevance 0.07 Pain Relevance 0.32
The contribution of urothelium and the effects of age and stretch of bladder strips on non-neuronal ACh release were evaluated.
Regulation (effects) of Localization (release) of ACh in neuronal
4) Confidence 0.11 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18285653 Disease Relevance 0 Pain Relevance 0.08
Exogenous 5-HT inhibits the paralytic effects of aldicarb but does not affect the sensitivity to levamisole (data not shown) [17], suggesting that 5-HT regulates presynaptic ACh release.
Regulation (regulates) of Localization (release) of ACh
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860991 Disease Relevance 0.47 Pain Relevance 0
BTX-A may block some of the autonomic vascular control functions and at the same time may alter the release of a variety of non-ACh agents that also affect blood flow.
Spec (may) Regulation (alter) of Localization (release) of ACh in blood
6) Confidence 0.00 Published 2007 Journal Trials Section Body Doc Link PMC2151066 Disease Relevance 0.82 Pain Relevance 1.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox