INT207229

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.52
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HBM)
Anatomy Link Frequency
blood 1
cleavage 1
bile 1
RBC 1
HBM (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 2 99.84 Very High Very High Very High
cytokine 12 97.44 Very High Very High Very High
Arthritis 12 66.20 Quite High
Osteoarthritis 56 50.00 Quite Low
Inflammatory response 4 46.32 Quite Low
Inflammatory mediators 2 36.64 Quite Low
fibrosis 7 9.20 Low Low
Inflammation 29 5.00 Very Low Very Low Very Low
spastic colon 23 5.00 Very Low Very Low Very Low
Crohn's disease 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thalassemia 21 99.04 Very High Very High Very High
Hemarthrosis 4 91.20 High High
Toxicity 6 89.64 High High
Hypertrophy 1 88.32 High High
Siderosis 8 87.04 High High
Synovitis 1 80.56 Quite High
Apoptosis 17 80.16 Quite High
Iron Overload 18 78.80 Quite High
Hemorrhage 8 68.40 Quite High
Arthritis 16 66.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another possibility is that hemorphins, known to be produced after enzymatic cleavage of hemoglobin, are responsible for behavioral alterations.
Protein_catabolism (cleavage) of hemoglobin in cleavage
1) Confidence 0.02 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
samples such as phenols, bile salts, degradation products of hemoglobin, and
Protein_catabolism (degradation) of hemoglobin in bile associated with bile
2) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 0 Pain Relevance 0.05
Hemoglobin degradation products such as deoxyhemoglobin, methemoglobin, and hemosiderin appear to mediate the blood-induced damage.
Protein_catabolism (degradation) of Hemoglobin in blood
3) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.88 Pain Relevance 0.12
Transfusion requirements are normally determined on the basis of a patientÂ’s hemoglobin level, but a rough approximation of the increased iron load can be estimated if one assumes that splenectomized patients might receive about 120 mL red blood cells (RBC)/kg each year, and non-splenectomized patients, who tend to have greater requirements, of about 160 mL RBC/kg each year because of enhanced degradation by overactive spleens (Thalassemia International Federation Guidelines 2000).
Protein_catabolism (degradation) of hemoglobin in RBC associated with thalassemia
4) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.64 Pain Relevance 0

General Comments

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