INT207229

Context Info Confidence 0.02 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.52 Pain Relevance 0.17

transport (HBM)

Anatomy Link Frequency blood 1 cleavage 1 bile 1 RBC 1 HBM (Homo sapiens)

Pain Link Frequency Relevance Heat Bile 2 99.84 cytokine 12 97.44 Arthritis 12 66.20 Osteoarthritis 56 50.00 Inflammatory response 4 46.32 Inflammatory mediators 2 36.64 fibrosis 7 9.20 Inflammation 29 5.00 spastic colon 23 5.00 Crohn's disease 22 5.00

Disease Link Frequency Relevance Heat Thalassemia 21 99.04 Hemarthrosis 4 91.20 Toxicity 6 89.64 Hypertrophy 1 88.32 Siderosis 8 87.04 Synovitis 1 80.56 Apoptosis 17 80.16 Iron Overload 18 78.80 Hemorrhage 8 68.40 Arthritis 16 66.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Another possibility is that hemorphins, known to be produced after enzymatic cleavage of hemoglobin, are responsible for behavioral alterations.

Protein_catabolism (cleavage) of hemoglobin in cleavage

1) Confidence 0.02 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0

samples such as phenols, bile salts, degradation products of hemoglobin, and

Protein_catabolism (degradation) of hemoglobin in bile associated with bile

2) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 0 Pain Relevance 0.05

Hemoglobin degradation products such as deoxyhemoglobin, methemoglobin, and hemosiderin appear to mediate the blood-induced damage.

Protein_catabolism (degradation) of Hemoglobin in blood

3) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.88 Pain Relevance 0.12

Transfusion requirements are normally determined on the basis of a patient’s hemoglobin level, but a rough approximation of the increased iron load can be estimated if one assumes that splenectomized patients might receive about 120 mL red blood cells (RBC)/kg each year, and non-splenectomized patients, who tend to have greater requirements, of about 160 mL RBC/kg each year because of enhanced degradation by overactive spleens (Thalassemia International Federation Guidelines 2000).

Protein_catabolism (degradation) of hemoglobin in RBC associated with thalassemia

4) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.64 Pain Relevance 0

General Comments

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