INT207238

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBB) transport (HBB)
Anatomy Link Frequency
blood 1
HBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 20.80 Low Low
tolerance 1 9.76 Low Low
amygdala 4 5.00 Very Low Very Low Very Low
Endogenous opioid 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Dynorphin 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 29 99.56 Very High Very High Very High
Infection 41 98.88 Very High Very High Very High
Asymptomatic Infections 17 98.88 Very High Very High Very High
Anaemia 21 96.36 Very High Very High Very High
Death 7 67.60 Quite High
Disease 5 65.52 Quite High
Stress 14 60.16 Quite High
Sickle Cell Anemia 6 53.76 Quite High
Hemorrhage 2 20.80 Low Low
Apoptosis 14 9.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-globin (Hbb-a) and ?
Hbb Binding (globin) of
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.07 Pain Relevance 0
To examine if an increased blood perfusion could be the main driver of the observed mRNA differences between S and NS foxes, we assumed that the average HBA and HBB levels (HB) may reflect the maximum effect of blood perfusion.
HBB Binding (average) of in blood
2) Confidence 0.20 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
The power to detect a dominance effect between the two parental lines (d = a) were 0.21, 0.47, 0.40, and 0.19 for HBA, HBB, HBE and HEBP1, respectively.
HBB Binding (0.19) of
3) Confidence 0.20 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.06 Pain Relevance 0
Two candidate genes, beta-globin and alpha-globin, were chosen because of their recognized impact on malaria parasite infection [16], [17], [19], [64], [65] and determinant role in anaemia [18], [36].
beta-globin Spec (determinant) Binding (recognized) of associated with malaria, anaemia and infection
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894056 Disease Relevance 1.00 Pain Relevance 0

General Comments

This test has worked.

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