INT207253

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.20
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS) carbohydrate metabolic process (INS) cytoplasm (TXNIP)
cell-cell signaling (INS) cytosol (TXNIP) extracellular space (INS)
INS (Homo sapiens)
TXNIP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 27 87.48 High High
dexamethasone 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 3 90.32 High High
Diabetes Mellitus 168 87.84 High High
Impaired Glucose Tolerance 24 87.48 High High
Hyperglycemia 6 81.36 Quite High
Obesity 51 81.04 Quite High
B-cell Lymphoma 3 78.96 Quite High
Insulin Resistance 36 5.00 Very Low Very Low Very Low
Prediabetic State 21 5.00 Very Low Very Low Very Low
Toxicity 15 5.00 Very Low Very Low Very Low
Parkinson's Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the suppression of TXNIP by insulin in vivo is simply secondary to a decrease in circulating glucose, or due to a direct effect of insulin signaling, we examined Txnip gene expression using published microarray data from mice with disrupted insulin receptor signaling [28,29].
insulin Spec (whether) Negative_regulation (suppression) of TXNIP
1) Confidence 0.45 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.87 Pain Relevance 0.15
These data indicate that the suppression of Txnip by insulin is not simply secondary to a reduction in circulating glucose concentrations, but rather or in addition, requires intact insulin receptor signaling.


insulin Negative_regulation (suppression) of Txnip
2) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.25 Pain Relevance 0
Of these three genes, G0S2 was strongly induced by insulin, while TXNIP and BCL6 were consistently repressed by insulin (Figure 1).
insulin Negative_regulation (repressed) of TXNIP
3) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.08 Pain Relevance 0

General Comments

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