INT207254

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF236, TXNIP) cytosol (TXNIP) intracellular (ZNF236)
cell cycle (TXNIP) DNA binding (ZNF236) cytoplasm (TXNIP)
Anatomy Link Frequency
pancreatic islets 1
nucleus 1
ZNF236 (Homo sapiens)
TXNIP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 18 78.32 Quite High
dexamethasone 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 92.52 High High
B-cell Lymphoma 2 81.80 Quite High
Impaired Glucose Tolerance 16 79.68 Quite High
Diabetes Mellitus 112 77.28 Quite High
Obesity 34 33.72 Quite Low
Targeted Disruption 2 12.96 Low Low
Insulin Resistance 24 5.00 Very Low Very Low Very Low
Prediabetic State 14 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Parkinson's Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is notable that whereas we identify TXNIP expression as being strongly repressed by insulin in vivo (Figure 1), many previous studies have identified TXNIP as being sharply induced by glucose in a variety of cell types, including pancreatic islets [35], fibroblasts [36], mesangial kidney cells [37], rat cardiomyocytes, and vascular endothelial and smooth muscle cells [38].


glucose Positive_regulation (induced) of TXNIP in pancreatic islets
1) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.42 Pain Relevance 0.06
Because these forkhead family members are known to be excluded from the nucleus via Akt-mediated phosphorylation downstream of insulin signaling [41], and since TXNIP induction by glucose is blunted by the activation of the phosphatidylinositol-3-kinase/Akt pathway [38], this class of transcription factors represent excellent candidate mediators of the insulin-stimulated repression of TXNIP.


glucose Positive_regulation (induction) of TXNIP in nucleus associated with repression
2) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.26 Pain Relevance 0.06

General Comments

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