INT207258

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.87
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TXNIP, ZNF236) cytosol (TXNIP) intracellular (ZNF236)
DNA binding (ZNF236) cell cycle (TXNIP) cytoplasm (TXNIP)
Anatomy Link Frequency
body 1
TXNIP (Homo sapiens)
ZNF236 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 36 48.72 Quite Low
dexamethasone 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 224 98.28 Very High Very High Very High
Insulin Resistance 48 94.52 High High
Obesity 68 85.64 High High
Disease 12 84.64 Quite High
Prediabetic State 28 81.44 Quite High
Birth Weight 4 78.56 Quite High
Impaired Glucose Tolerance 32 48.72 Quite Low
Repression 4 35.04 Quite Low
Toxicity 20 25.00 Low Low
Renal Failure 4 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results provide strong evidence that TXNIP is a regulator of glucose homeostasis in people.
TXNIP Regulation (regulator) of glucose
1) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.55 Pain Relevance 0
To directly test if TXNIP may regulate glucose uptake, we used genetic manipulations to alter the gene's expression in mouse and human cell lines.
TXNIP Spec (may) Regulation (regulate) of glucose
2) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.44 Pain Relevance 0
Specifically, the researchers propose that TXNIP regulates glucose uptake in the periphery of the human body by acting as a glucose- and insulin-sensitive switch.
TXNIP Regulation (regulates) of glucose in body
3) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.54 Pain Relevance 0
While the above studies demonstrate that TXNIP is a physiologic regulator of peripheral glucose homeostasis in humans, we were next interested in determining whether genetic variation in this gene may be associated with measures of insulin resistance or T2DM in humans.
TXNIP Regulation (regulator) of glucose associated with diabetes mellitus and insulin resistance
4) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.35 Pain Relevance 0

General Comments

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