INT207260

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS) carbohydrate metabolic process (INS) cytoplasm (TXNIP)
cell-cell signaling (INS) cytosol (TXNIP) extracellular space (INS)
Anatomy Link Frequency
arms 2
INS (Homo sapiens)
TXNIP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 27 11.48 Low Low
dexamethasone 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 168 89.92 High High
Prediabetic State 21 86.96 High High
Disease 9 76.32 Quite High
Parkinson's Disease 9 75.04 Quite High
Obesity 51 73.76 Quite High
Insulin Resistance 36 68.88 Quite High
Toxicity 15 66.08 Quite High
Myocardial Infarction 3 60.44 Quite High
Renal Failure 3 59.72 Quite High
Targeted Disruption 3 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TXNIP expression increased following elevations in glucose concentration, and was suppressed by insulin (Figure 3).
insulin Negative_regulation (suppressed) of Gene_expression (expression) of TXNIP
1) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.13 Pain Relevance 0
Because TXNIP expression is suppressed by insulin signaling, it appears that TXNIP influences both insulin-dependent and insulin-independent arms of glucose uptake into cells.
insulin Negative_regulation (suppressed) of Gene_expression (expression) of TXNIP in arms
2) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.65 Pain Relevance 0
One of the latter genes was thioredoxin interacting protein (TXNIP), a gene whose expression is strongly induced by glucose yet suppressed by insulin.
insulin Negative_regulation (suppressed) of Gene_expression (expression) of TXNIP
3) Confidence 0.33 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.94 Pain Relevance 0

General Comments

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