INT207264

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF236, TXNIP) cytosol (TXNIP) intracellular (ZNF236)
cell cycle (TXNIP) DNA binding (ZNF236) cytoplasm (TXNIP)
Anatomy Link Frequency
fat 3
muscle 1
ZNF236 (Homo sapiens)
TXNIP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 36 17.12 Low Low
dexamethasone 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 224 94.84 High High
Prediabetic State 28 94.48 High High
Toxicity 20 89.36 High High
Obesity 68 67.12 Quite High
Insulin Resistance 48 62.24 Quite High
Targeted Disruption 4 46.36 Quite Low
Repression 4 41.76 Quite Low
Hyperglycemia 8 37.40 Quite Low
Parkinson's Disease 12 31.04 Quite Low
Impaired Glucose Tolerance 32 17.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Key novel results from the current study include the finding that TXNIP gene expression is reciprocally regulated by insulin and by glucose, that elevations in TXNIP can inhibit glucose uptake, and that TXNIP expression levels are consistently elevated in humans with T2DM and prediabetes.
glucose Regulation (regulated) of Gene_expression (expression) of TXNIP gene associated with diabetes mellitus and prediabetic state
1) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.63 Pain Relevance 0
Together, these cell culture studies confirm that TXNIP expression is reciprocally regulated by insulin and glucose in human muscle and fat tissues.


glucose Regulation (regulated) of Gene_expression (expression) of TXNIP in fat
2) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.07 Pain Relevance 0
We hypothesized that the reciprocal regulation of TXNIP expression by insulin and glucose is likely mediated by highly conserved regulatory elements in the vicinity of its promoter (Figure S2).
glucose Regulation (regulation) of Gene_expression (expression) of TXNIP
3) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.06 Pain Relevance 0
Together, these cell culture studies confirm that TXNIP expression is reciprocally regulated by insulin and glucose in human muscle and fat tissues.


glucose Regulation (regulated) of in muscle Gene_expression (expression) of TXNIP in fat
4) Confidence 0.01 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.07 Pain Relevance 0

General Comments

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