INT207265

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF236, TXNIP) cytosol (TXNIP) intracellular (ZNF236)
cell cycle (TXNIP) DNA binding (ZNF236) cytoplasm (TXNIP)
ZNF236 (Homo sapiens)
TXNIP (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 18 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 24 94.60 High High
Parkinson's Disease 6 91.56 High High
Diabetes Mellitus 112 89.92 High High
Prediabetic State 14 84.88 Quite High
Disease 6 76.32 Quite High
Myocardial Infarction 2 60.44 Quite High
Renal Failure 2 59.72 Quite High
Toxicity 10 36.84 Quite Low
Hyperglycemia 4 36.00 Quite Low
Obesity 34 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, TXNIP expression is induced by glucocorticoids [49] and by glucose, and TXNIP elevations can stimulate ROS production [38].
glucose Positive_regulation (induced) of Gene_expression (expression) of TXNIP
1) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.67 Pain Relevance 0
One of the latter genes was thioredoxin interacting protein (TXNIP), a gene whose expression is strongly induced by glucose yet suppressed by insulin.
glucose Positive_regulation (induced) of Gene_expression (expression) of TXNIP
2) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.93 Pain Relevance 0

General Comments

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