INT207282

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.64
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF236) intracellular (ZNF236) DNA binding (ZNF236)
Anatomy Link Frequency
muscle 3
adipocyte 1
ZNF236 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 72 98.68 Very High Very High Very High
dexamethasone 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 448 99.08 Very High Very High Very High
Impaired Glucose Tolerance 64 98.68 Very High Very High Very High
Targeted Disruption 8 96.08 Very High Very High Very High
Hyperglycemia 16 94.08 High High
Obesity 136 90.68 High High
Birth Weight 8 83.60 Quite High
Insulin Resistance 96 62.64 Quite High
B-cell Lymphoma 8 43.76 Quite Low
Repression 8 40.08 Quite Low
Prediabetic State 56 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Again, we observed a significant increase in both basal and insulin-stimulated glucose uptake (Figure 5C).
Positive_regulation (increase) of glucose
1) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.28 Pain Relevance 0
These data are consistent with the notion that TXNIP is an independent determinant of insulin-stimulated glucose uptake in humans.


Positive_regulation (stimulated) of glucose
2) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.56 Pain Relevance 0.05
TXNIP expression increased following elevations in glucose concentration, and was suppressed by insulin (Figure 3).
Positive_regulation (increased) of glucose
3) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.13 Pain Relevance 0
We also performed in vitro assays of TXNIP expression in a human adipocyte cell line (Methods) that is known to respond to insulin by stimulating glucose uptake.
Positive_regulation (stimulating) of glucose in adipocyte
4) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.13 Pain Relevance 0
Txnip expression levels reverted (0.53-fold, p < 0.05) to baseline in the muscle of these mice following treatment with insulin, which normalizes circulating glucose levels.
Positive_regulation (circulating) of glucose in muscle
5) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.48 Pain Relevance 0.03
To relate expression data with insulin-stimulated glucose uptake, a GEE model was used to adjust for the interdependence between twins [9,30].
Positive_regulation (stimulated) of glucose
6) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.14 Pain Relevance 0
Although elevated circulating glucose levels could account for the observed differences in IGT and T2DM, it is notable that in our previous study [18], presented in Figure 2A, the muscle biopsies were obtained during conditions in which plasma glucose was clamped at the same level in all individuals.


Positive_regulation (elevated) of glucose in muscle associated with diabetes mellitus and tolerance
7) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.97 Pain Relevance 0.18
Although elevated circulating glucose levels could account for the observed differences in IGT and T2DM, it is notable that in our previous study [18], presented in Figure 2A, the muscle biopsies were obtained during conditions in which plasma glucose was clamped at the same level in all individuals.


Positive_regulation (account) of glucose in muscle associated with diabetes mellitus and tolerance
8) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.96 Pain Relevance 0.17

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