INT207284

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.02
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF236) intracellular (ZNF236) DNA binding (ZNF236)
Anatomy Link Frequency
muscle 1
heart 1
ZNF236 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 45 51.68 Quite High
dexamethasone 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prediabetic State 35 97.00 Very High Very High Very High
Renal Failure 5 96.80 Very High Very High Very High
Apoptosis 5 96.76 Very High Very High Very High
Targeted Disruption 5 96.60 Very High Very High Very High
Diabetes Mellitus 280 96.36 Very High Very High Very High
Death 5 96.04 Very High Very High Very High
Myocardial Infarction 5 96.04 Very High Very High Very High
Insulin Resistance 60 92.76 High High
Toxicity 25 88.88 High High
Hyperglycemia 10 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the muscle insulin receptor knockout mouse [29], treatment of streptozotocin-treated mice with insulin failed to suppress Txnip expression (1.33-fold increase with insulin, p = 0.08), despite the fact that glucose was well controlled in these mice.
Regulation (controlled) of glucose in muscle associated with targeted disruption
1) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.36 Pain Relevance 0.03
Our study shows that TXNIP is part of a negative feedback mechanism that regulates glucose uptake into cells (Figure 7A).
Regulation (regulates) of glucose
2) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.62 Pain Relevance 0
The researchers then examined whether TXNIP expression was correlated with glucose uptake, again using previously published data.
Spec (whether) Regulation (correlated) of glucose
3) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.77 Pain Relevance 0
These changes result in poor glucose homeostasis (inadequate control of blood sugar levels), which can cause life-threatening complications such as kidney failure and heart attacks.


Regulation (control) of glucose in heart associated with renal failure and myocardial infarction
4) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 1.37 Pain Relevance 0
Our present study has led to the novel finding that TXNIP also plays a role in controlling peripheral glucose uptake in humans and may be an important target mediating effects of insulin.
Regulation (controlling) of glucose
5) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.89 Pain Relevance 0

General Comments

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