INT207289

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.00
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (G0S2) lipid particle (G0S2) cell cycle (G0S2)
molecular_function (G0S2) cellular_component (G0S2)
Anatomy Link Frequency
thyroid 1
muscle tissue 1
G0S2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 67.72 Quite High
Inflammation 30 66.16 Quite High
cytokine 12 40.56 Quite Low
tolerance 18 26.72 Quite Low
fibrosis 2 12.80 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 8 98.76 Very High Very High Very High
Infection 62 96.84 Very High Very High Very High
Eyelid Disease 2 91.28 High High
Thyroid Disease 44 90.96 High High
Graves' Ophthalmopathy 62 90.28 High High
B-cell Lymphoma 2 89.28 High High
Disease 28 85.52 High High
Thyroiditis 66 79.44 Quite High
Obesity 36 70.00 Quite High
Ocular & Orbital Inflammation 6 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
G0S2 was recently shown to be a target gene of PPAR?
Gene_expression (shown) of G0S2
1) Confidence 0.59 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.09 Pain Relevance 0
After stringent correction for multiple hypotheses testing, we identified three genes (G0S2, TXNIP, and BCL6) (Table 1) exhibiting differential expression before and after insulin treatment in both studies.
Gene_expression (expression) of G0S2
2) Confidence 0.53 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.07 Pain Relevance 0
The expression of CLU was up-regulated, while the expression of G0S2 was down-regulated [11].
Gene_expression (expression) of G0S2
3) Confidence 0.09 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.43 Pain Relevance 0.03
As shown in Table 3, expression change of many cell cycle-related factors was observed in Trichinella infected muscle tissue, for example, retinoblastoma (Rb), CDK4, cyclin C, cyclin B2, cyclin D2 and cyclin D3, CLU, G0/G1 switch gene 2 (G0S2), inhibitor of DNA binding 2 (Id2), myeloblastosis oncogene (Myb), and N-myc downstream regulated gene 2 (Ndrg2) [9,11].
Gene_expression (/) of G0S2 in muscle tissue associated with retinoblastoma
4) Confidence 0.08 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2538513 Disease Relevance 0.46 Pain Relevance 0
The orbital antigen, Fp, was also found to be significantly up-regulated, 1.4-fold, while genes encoding collagen XIII, FOXP1/G2s, thyroglobulin, thyroid peroxidise and the TSH-r, were not differentially expressed.48
Neg (not) Gene_expression (expressed.48) of G2s in thyroid
5) Confidence 0.00 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.13 Pain Relevance 0
Finally, positive antibody reactivity against calsequestrin and collagen XIII was not observed in any of the healthy controls, while Fp and G2s antibodies were found in 14.3% and 4.8% respectively, of controls.35
Gene_expression (antibodies) of G2s
6) Confidence 0.00 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.83 Pain Relevance 0.03

General Comments

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