INT207292

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 5.78
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ZNF236) intracellular (ZNF236) DNA binding (ZNF236)
Anatomy Link Frequency
body 3
muscle 1
pancreas 1
skeletal muscle 1
ZNF236 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 162 98.12 Very High Very High Very High
anesthesia 18 80.04 Quite High
alcohol 18 68.92 Quite High
dexamethasone 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 90 100.00 Very High Very High Very High
Prediabetic State 126 99.00 Very High Very High Very High
Diabetes Mellitus 1008 98.24 Very High Very High Very High
Impaired Glucose Tolerance 144 98.12 Very High Very High Very High
Obesity 306 97.74 Very High Very High Very High
Repression 18 92.24 High High
Rheumatoid Arthritis 18 90.80 High High
Apoptosis 18 89.92 High High
Death 18 89.20 High High
Birth Weight 18 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The glucose uptake and glucose oxidation were expressed per kilogram of lean body mass as determined by DEXA scan as previously described [10].
Gene_expression (expressed) of glucose in body
1) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0 Pain Relevance 0.08
Previously published results suggest that this would induce the loss of insulin-producing cells in the pancreas, thus further reducing insulin production and glucose uptake in the periphery and, ultimately, resulting in type 2 diabetes.
Gene_expression (production) of glucose in pancreas associated with diabetes mellitus
2) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.45 Pain Relevance 0
Together, these in vitro studies indicate that changes in TXNIP expression can directly influence glucose uptake in insulin-responsive cells.


Gene_expression (uptake) of glucose
3) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.30 Pain Relevance 0
We hypothesized that the reciprocal regulation of TXNIP expression by insulin and glucose is likely mediated by highly conserved regulatory elements in the vicinity of its promoter (Figure S2).
Gene_expression (expression) of glucose
4) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.06 Pain Relevance 0
Although elevated circulating glucose levels could account for the observed differences in IGT and T2DM, it is notable that in our previous study [18], presented in Figure 2A, the muscle biopsies were obtained during conditions in which plasma glucose was clamped at the same level in all individuals.


Gene_expression (levels) of glucose in muscle associated with diabetes mellitus and tolerance
5) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.96 Pain Relevance 0.17
A variable infusion of glucose (180 g/l) enriched with tritiated glucose (100 ?
Gene_expression (infusion) of glucose
6) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.17 Pain Relevance 0.06
A primed continuous infusion of a 3-[3H]-glucose tracer was supplied from the time point ?
Gene_expression (tracer) of glucose
7) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.24 Pain Relevance 0.13
-cells and in the periphery, helping to reconcile the dynamic relationship between insulin deficiency and impaired glucose uptake that is observed in the prediabetic state (Figure 7B).
Gene_expression (uptake) of glucose associated with prediabetic state
8) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.85 Pain Relevance 0
Insulin-stimulated glucose uptake was defined as the glucose infusion rate during steady state of the clamp.
Gene_expression (uptake) of glucose
9) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0 Pain Relevance 0.08
Basal (p = 0.02) and insulin-stimulated (p < 0.01) TXNIP expression as well as BMI (p < 0.01) were inversely correlated, while VO2max (p < 0.01) was positively correlated with insulin-stimulated glucose uptake (Table 2).
Gene_expression (uptake) of glucose associated with obesity
10) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.58 Pain Relevance 0.06
We found that TXNIP expression is inversely correlated with the total body rate of insulin-stimulated glucose metabolism in humans (Figure 4).
Gene_expression (metabolism) of glucose in body
11) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.43 Pain Relevance 0.09
Nonoxidative glucose metabolism was calculated as glucose uptake minus glucose oxidation as determined by indirect calorimetry.


Gene_expression (oxidation) of glucose
12) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0 Pain Relevance 0.07
To relate expression data with insulin-stimulated glucose uptake, a GEE model was used to adjust for the interdependence between twins [9,30].
Gene_expression (expression) of glucose
13) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.14 Pain Relevance 0
Together, these studies suggest that TXNIP may be involved in glucose toxicity both in ?
Gene_expression (toxicity) of glucose associated with toxicity
14) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.87 Pain Relevance 0
Nonoxidative glucose metabolism was calculated as glucose uptake minus glucose oxidation as determined by indirect calorimetry.


Gene_expression (metabolism) of glucose
15) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0 Pain Relevance 0.07
A variable infusion of glucose (180 g/l) enriched with tritiated glucose (100 ?
Gene_expression (enriched) of glucose
16) Confidence 0.04 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.16 Pain Relevance 0.06
To exclude the possibility that the relationship between TXNIP expression and glucose uptake could be a consequence, rather than a cause, of the metabolic derangements that precede T2DM we also related the expression of skeletal muscle TXNIP to glucose uptake in 96 healthy, young, nondiabetic individuals (Methods, study C).
Gene_expression (expression) of glucose in skeletal muscle associated with diabetes mellitus
17) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.57 Pain Relevance 0.09
The glucose uptake and glucose oxidation were expressed per kilogram of lean body mass as determined by DEXA scan as previously described [10].
Gene_expression (expressed) of glucose in body
18) Confidence 0.03 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0 Pain Relevance 0.08

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