INT207293

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.00
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
Pancreatic islets 2
blood 2
pancreas 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 19 88.64 High High
antagonist 4 85.28 High High
tolerance 25 81.60 Quite High
Action potential 1 67.28 Quite High
ketamine 2 52.08 Quite High
alcohol 2 47.44 Quite Low
anesthesia 3 45.84 Quite Low
Inflammation 6 39.04 Quite Low
withdrawal 4 29.84 Quite Low
agonist 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 71 100.00 Very High Very High Very High
Vibrio Infection 1 100.00 Very High Very High Very High
Diphtheria 1 100.00 Very High Very High Very High
Autoimmune Disease 5 99.70 Very High Very High Very High
Pressure And Volume Under Development 15 98.88 Very High Very High Very High
Disease 37 98.48 Very High Very High Very High
Weight Gain 18 98.44 Very High Very High Very High
Diabetes Mellitus 471 96.56 Very High Very High Very High
Hypertension 35 94.44 High High
Death 11 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent clinical trials of antigen-specific or non-specific immune therapies have proved that modulation of islet specific autoimmunity in humans and prevention of insulin secretion loss in the short term after the onset of disease is achievable.
Negative_regulation (prevention) of Negative_regulation (loss) of insulin associated with autoimmune disease and disease
1) Confidence 0.49 Published 2008 Journal Diabetic Medicine Section Abstract Doc Link PMC2701557 Disease Relevance 0.61 Pain Relevance 0.03
A primed continuous infusion of insulin (low dose 40 mU · m?
Negative_regulation (infusion) of Negative_regulation (dose) of insulin
2) Confidence 0.43 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2571046 Disease Relevance 0.16 Pain Relevance 0
the patient with a predictable baseline level of insulin throughout the day,
Negative_regulation (predictable) of Negative_regulation (level) of insulin
3) Confidence 0.43 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0 Pain Relevance 0.09
Adding rosiglitazone to insulin therapy was found to reduce glycated haemoglobin (HbA1c) by 1.2% (P < 0.001), along with a 12% reduction of insulin dosage, but with increased oedema and weight gain [19,20].
Negative_regulation (reduce) of Negative_regulation (reduction) of insulin associated with pressure and volume under development and weight gain
4) Confidence 0.42 Published 2007 Journal Diabetic Medicine Section Body Doc Link PMC1974817 Disease Relevance 0.56 Pain Relevance 0
where X(t) = insulin action at minute (t), I(t) = insulin concentration at minute (t), Ib = baseline insulin concentration, P2 = loss rate of insulin action (X), P3 = action of one unit insulin on glucose disposal per minute
Negative_regulation (minute) of Negative_regulation (action) of insulin
5) Confidence 0.40 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2911461 Disease Relevance 0.25 Pain Relevance 0.06
Usually, the effect of the NPH insulin is very slow and continues for a long
Negative_regulation (slow) of Negative_regulation (effect) of insulin
6) Confidence 0.37 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 0.48 Pain Relevance 0
Thus, an improvement of insulin resistance state and a decrease in plasma insulin level may be very important for the reduction of arterial stiffening, in addition to blood pressure control, even in non diabetic hypertensives.
Negative_regulation (improvement) of Negative_regulation (decrease) of insulin in blood associated with diabetes mellitus and insulin resistance
7) Confidence 0.37 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994018 Disease Relevance 1.43 Pain Relevance 0.08
Previously published results suggest that this would induce the loss of insulin-producing cells in the pancreas, thus further reducing insulin production and glucose uptake in the periphery and, ultimately, resulting in type 2 diabetes.
Negative_regulation (reducing) of Negative_regulation (loss) of insulin in pancreas associated with diabetes mellitus
8) Confidence 0.29 Published 2007 Journal PLoS Medicine Section Abstract Doc Link PMC1858708 Disease Relevance 0.51 Pain Relevance 0
The last is evident initially as impaired first-phase insulin secretion in response to oral, or intravenous, glucose and progresses at a variable rate to absolute insulin deficiency, reflecting ?
Negative_regulation (progresses) of Negative_regulation (deficiency) of insulin
9) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 1.39 Pain Relevance 0
Pancreatic islets exposed to high concentrations of NEFAs for periods of 24–48 h [3] display enhanced insulin secretion in the presence of a non-stimulatory glucose concentration, decreased insulin synthesis, depletion of stored insulin and an impaired response of the ?
Negative_regulation (decreased) of Negative_regulation (depletion) of insulin in Pancreatic islets
10) Confidence 0.09 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
Over a long period of time, however, F decreases the insulin inhibition of hepatic glucose production, leading to hepatic insulin resistance.
Negative_regulation (decreases) of Negative_regulation (inhibition) of insulin associated with insulin resistance
11) Confidence 0.08 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.23 Pain Relevance 0
The toxin’s structure is similar to insulin, ricin, botulinum, cholera and diphtheria toxins.1 The B chain facilitates binding to cell surface receptors, allowing the entry of the A chain into cells.4 The A chain acts on the 60s ribosome to inhibit EF-1 and EF-2, preventing protein synthesis and leading to cell death.1,5
Negative_regulation (similar) of Negative_regulation (facilitates) of insulin associated with vibrio infection, diphtheria and death
12) Confidence 0.08 Published 2008 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2672262 Disease Relevance 0.37 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox