INT207304

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.08
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brains 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 44 67.20 Quite High
imagery 38 11.52 Low Low
Thalamus 27 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 61 98.88 Very High Very High Very High
Scrapie 103 98.44 Very High Very High Very High
Stress 30 97.04 Very High Very High Very High
Death 17 92.16 High High
Creutzfeldt Jakob Disease 88 92.08 High High
Injury 6 86.00 High High
Cv Unclassified Under Development 32 67.20 Quite High
Brain Hemorrhage 16 53.48 Quite High
Adhesions 2 52.96 Quite High
Coronary Artery Disease 12 44.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, they do not allow us to discriminate whether the reduction in PrPSc levels is due to impaired production or to enhanced degradation of PrPSc.
Positive_regulation (enhanced) of Protein_catabolism (degradation) of PrPSc
1) Confidence 0.69 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Altogether, these results indirectly suggest that the observed decrease in PrPSc levels in Rab22-expressing cells is not due to increased delivery and degradation of PrPSc in LEs, but rather is due to impaired scrapie production.
Positive_regulation (increased) of Protein_catabolism (degradation) of PrPSc associated with scrapie
2) Confidence 0.69 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0
On the the other hand, if the decrease of PrPSc levels by Rab22a-expression was not due to increased PrPSc degradation but rather to inhibition of PrPSc synthesis, NH4Cl treatment should not interfere and we should still observe a decrease in PrPSc levels.
Positive_regulation (increased) of Protein_catabolism (degradation) of PrPSc
3) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
In this study we detected an increased degradation of PrPC FL to its breakdown product C1 in the area surrounding the infarct and in the contralateral hemisphere in Prnp+/+ mouse brains.
Positive_regulation (increased) of Protein_catabolism (degradation) of PrPC in brains
4) Confidence 0.50 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.59 Pain Relevance 0.05
This finding is in agreement with Mangé’s postulation of increased PrPC degradation under oxidative conditions (20).
Positive_regulation (increased) of Protein_catabolism (degradation) of PrPC
5) Confidence 0.47 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.66 Pain Relevance 0.03
In contrast to PrPC, which is completely degraded by PK, only partial degradation of PrPSc occurs in this condition [73].
Positive_regulation (occurs) of Protein_catabolism (degradation) of PrPSc
6) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
In contrast to PrPC, which is completely degraded by PK, only partial degradation of PrPSc occurs in this condition [73].
Positive_regulation (occurs) of Protein_catabolism (degraded) of PrPC
7) Confidence 0.46 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
It is not clear whether autophagy plays a disease promoting role or a disease defensive role since activation of autophagic vacuoles promotes degradation of PrPSc and a prolongation of incubation time [27].
Positive_regulation (promotes) of Protein_catabolism (degradation) of PrPSc associated with disease
8) Confidence 0.45 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.56 Pain Relevance 0
To further test this hypothesis and to discriminate between increased degradation and decreased production of PrPSc, we compared the levels of PrPSc in control cells and in cells transfected with GFP-Rab22a after treating them with ammonium chloride (NH4Cl), which impairs lysosomal degradation [43].
Positive_regulation (increased) of Protein_catabolism (degradation) of PrPSc
9) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0

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