INT207325

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.61
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
joint 2
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 260 100.00 Very High Very High Very High
rheumatoid arthritis 50 98.90 Very High Very High Very High
imagery 16 71.08 Quite High
Inflammation 56 68.64 Quite High
Arthritis 98 67.60 Quite High
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 10 99.20 Very High Very High Very High
Rheumatoid Arthritis 50 98.90 Very High Very High Very High
Toxicity 4 88.80 High High
Arthritis 124 68.64 Quite High
INFLAMMATION 48 50.64 Quite High
Hypercalcemia 14 47.44 Quite Low
Osteoporosis 16 46.80 Quite Low
Body Weight 4 35.52 Quite Low
Solid Tumor 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the incubation temperature increased from 4°C to 37°C, the Dex releasing rate was greatly increased.
Positive_regulation (increased) of Localization (releasing) of Dex associated with dexamethasone
1) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.10 Pain Relevance 0.58
To activate the prodrug, two conditions must be met: (a) a pathological condition (for example, neovascularization in RA joint) that would allow local enrichment of the prodrug and (b) an acidic environment (for example, RA joint acidosis and lysosomal compartments) that would trigger the release of active Dex from the polymer carrier.
Positive_regulation (trigger) of Localization (release) of Dex in joint associated with acidosis, rheumatoid arthritis and dexamethasone
2) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.50 Pain Relevance 0.40

General Comments

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