INT207355

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP27A1) small molecule metabolic process (CYP27A1) nucleus (ZNF398)
intracellular (ZNF398) DNA binding (ZNF398)
Anatomy Link Frequency
THP-1 1
ZNF398 (Homo sapiens)
CYP27A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 26 100.00 Very High Very High Very High
cINOD 20 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 18 5.00 Very Low Very Low Very Low
Myocardial Infarction 16 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Thrombosis 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Cardiovascular Disease 4 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, TXA2 failed to reverse the effect of NS398 on either 27-hydroxylase or ABCA1 message.
NS398 Regulation (effect) of 27-hydroxylase
1) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.16
Effects of the specific COX-2 inhibitor NS398 on 27-hydroxylase and ABCA1 level in THP-1 monocytes were reversed by PGE1, PGE2, and PGD2 prostaglandin products of COX-2 (Figure 5).


NS398 Regulation (Effects) of 27-hydroxylase in THP-1 associated with cox-2 inhibitor
2) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.14

General Comments

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