INT207370

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 2.75
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
macrophages 6
liver 2
monocytes 2
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 104 91.28 High High
diclofenac 8 77.72 Quite High
cINOD 80 76.88 Quite High
Inflammation 40 61.32 Quite High
Pain 24 60.64 Quite High
Arthritis 8 60.44 Quite High
Analgesic 8 21.76 Low Low
withdrawal 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 24 97.44 Very High Very High Very High
Atherosclerosis 72 94.76 High High
Myocardial Infarction 64 81.08 Quite High
INFLAMMATION 56 76.32 Quite High
Pain 24 60.64 Quite High
Arthritis 8 60.44 Quite High
Stroke 24 53.88 Quite High
Heart Disease 8 53.44 Quite High
Adenomatous Polyps 8 27.12 Quite Low
Thrombosis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).
Negative_regulation (inhibition) of Gene_expression (expression) of ABCA1 in macrophages
1) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.57 Pain Relevance 0.38
We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).
Negative_regulation (reduced) of Gene_expression (expression) of ABCA1 in macrophages
2) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.56 Pain Relevance 0.37
Similar to 27-hydroxylase, ABCA1 message was reduced after NS398 exposure to approximately 70% of control (50 ?
Negative_regulation (reduced) of Gene_expression (message) of ABCA1
3) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
The non-selective COX inhibitor indomethacin also produced a significant reduction in cholesterol 27-hydroxylase and ABCA1 mRNA expression (50 ?
Negative_regulation (reduction) of Gene_expression (expression) of ABCA1 mRNA
4) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.06
We therefore examined the effect of non-selective and selective COX-1 inhibitors on 27-hydroxylase and ABCA1 expression.


Spec (examined) Negative_regulation (inhibitors) of Gene_expression (expression) of ABCA1
5) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
Negative_regulation (diminish) of Gene_expression (expression) of transporter A1 in liver associated with atherosclerosis
6) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.50 Pain Relevance 0.23
We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).
Negative_regulation (inhibition) of in monocytes Gene_expression (expression) of ABCA1 in macrophages
7) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.57 Pain Relevance 0.38
We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).
Negative_regulation (reduced) of in monocytes Gene_expression (expression) of ABCA1 in macrophages
8) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.56 Pain Relevance 0.37

General Comments

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