INT207376

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
osteoclast 2
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 38 95.48 Very High Very High Very High
Arthritis 34 84.88 Quite High
dorsal root ganglion 3 78.88 Quite High
cytokine 28 71.04 Quite High
Inflammation 71 70.64 Quite High
Demyelination 6 60.72 Quite High
Crohn's disease 7 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 98.64 Very High Very High Very High
Rheumatoid Arthritis 40 95.48 Very High Very High Very High
Arthritis 32 84.88 Quite High
Ganglion Cysts 3 78.88 Quite High
INFLAMMATION 68 70.64 Quite High
Osteoporosis 1 63.92 Quite High
Adhesions 3 62.88 Quite High
Demyelinating Disease 7 60.72 Quite High
Seronegative Spondarthritis 4 56.08 Quite High
Necrosis 3 33.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-receptor type 1 involves mitogen-activated protein kinases (MAPKs) and NFkB, which then activate key transcription factors for osteoclast formation, such as c-fos of the activator protein-1 family or NFATc1.
Positive_regulation (activate) of Transcription (transcription) of NFATc1 in osteoclast
1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.73 Pain Relevance 0.37
B inhibitor pyrrolidine dithiocarbamate (20), the NFAT-specific inhibitory 3,5-bistrifluoromethyl pyrazole derivative BTP1 (21), and the calcineurin-inhibitor cyclosporine A (22) all blocked the PMA/ionomycin-induced expression of twist1 mRNA (Fig. 3 B), showing that both NFAT and NF-?
Positive_regulation (induced) of Transcription (expression) of NFAT
2) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
In addition to transcription factors that promote myelination, such as NFAT, NF-?
Positive_regulation (promote) of Transcription (transcription) of NFAT
3) Confidence 0.07 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.41 Pain Relevance 0.10

General Comments

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