INT207380

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.32
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nfatc1) DNA binding (Nfatc1) cytoplasm (Nfatc1)
Anatomy Link Frequency
NFAT 3
osteoclast 1
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 38 94.96 High High
Arthritis 34 84.88 Quite High
dorsal root ganglion 3 78.88 Quite High
cytokine 301 70.52 Quite High
Inflammation 359 70.12 Quite High
Demyelination 6 60.72 Quite High
antagonist 103 5.00 Very Low Very Low Very Low
chemokine 73 5.00 Very Low Very Low Very Low
agonist 60 5.00 Very Low Very Low Very Low
Inflammatory response 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 64 98.64 Very High Very High Very High
Rheumatoid Arthritis 40 94.96 High High
Arthritis 32 84.88 Quite High
Ganglion Cysts 3 78.88 Quite High
Asthma 945 73.48 Quite High
INFLAMMATION 377 70.12 Quite High
Osteoporosis 1 63.92 Quite High
Adhesions 15 62.88 Quite High
Demyelinating Disease 7 60.72 Quite High
Seronegative Spondarthritis 4 55.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-receptor type 1 involves mitogen-activated protein kinases (MAPKs) and NFkB, which then activate key transcription factors for osteoclast formation, such as c-fos of the activator protein-1 family or NFATc1.
Transcription (transcription) of NFATc1 in osteoclast
1) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.68 Pain Relevance 0.34
The NFAT family of transcription factors include the cytoplasmic NFAT transcription factors [NFATc1 (NFATc), NFATc2 (NFATp), NFATc3 (NFAT4, NFATx), NFATc4 (NFAT3), NFATc5] and nuclear NFAT (NFATn).
Transcription (transcription) of NFATc in NFAT
2) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.07 Pain Relevance 0.03
The NFAT family of transcription factors include the cytoplasmic NFAT transcription factors [NFATc1 (NFATc), NFATc2 (NFATp), NFATc3 (NFAT4, NFATx), NFATc4 (NFAT3), NFATc5] and nuclear NFAT (NFATn).
Transcription (transcription) of NFAT in NFAT
3) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.07 Pain Relevance 0.03
The NFAT family of transcription factors include the cytoplasmic NFAT transcription factors [NFATc1 (NFATc), NFATc2 (NFATp), NFATc3 (NFAT4, NFATx), NFATc4 (NFAT3), NFATc5] and nuclear NFAT (NFATn).
Transcription (transcription) of nuclear NFAT in NFAT
4) Confidence 0.18 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.07 Pain Relevance 0.03
B inhibitor pyrrolidine dithiocarbamate (20), the NFAT-specific inhibitory 3,5-bistrifluoromethyl pyrazole derivative BTP1 (21), and the calcineurin-inhibitor cyclosporine A (22) all blocked the PMA/ionomycin-induced expression of twist1 mRNA (Fig. 3 B), showing that both NFAT and NF-?
Transcription (expression) of NFAT
5) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
In addition to transcription factors that promote myelination, such as NFAT, NF-?
Transcription (transcription) of NFAT
6) Confidence 0.10 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.41 Pain Relevance 0.10

General Comments

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