INT207383

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 6.39
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joints 2
granulocytes 1
bone marrow 1
osteoclasts 1
Pgia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 320 100.00 Very High Very High Very High
Inflammation 171 99.56 Very High Very High Very High
rheumatoid arthritis 223 98.78 Very High Very High Very High
agonist 4 69.16 Quite High
imagery 60 60.44 Quite High
cytokine 33 51.12 Quite High
Inflammatory response 3 50.04 Quite High
chemokine 9 44.48 Quite Low
Multiple sclerosis 27 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 395 100.00 Very High Very High Very High
INFLAMMATION 165 99.56 Very High Very High Very High
Rheumatoid Arthritis 224 98.78 Very High Very High Very High
Targeted Disruption 11 98.32 Very High Very High Very High
Disease 81 96.64 Very High Very High Very High
Severe Combined Immunodeficiency 168 96.56 Very High Very High Very High
Arthropathy 7 92.56 High High
Immunization 12 83.92 Quite High
Osteoporosis 2 81.80 Quite High
Osteopetrosis 2 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether FTY720 was also ineffective in suppressing or preventing arthritis in immunocompetent BALB/c mice, we administered placebo or FTY720 orally to BALB/c mice after immunizing them with PG in DDA adjuvant to induce the primary form of PGIA.
Positive_regulation (induce) of PGIA associated with arthritis
1) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.09 Pain Relevance 0.31
Although PGIA does not appear to be inducible via serum transfer ([12] and our unpublished data), neutrophils still vastly outnumber T cells in the inflamed joints in PG-immunized arthritic BALB/c mice and in SCID mice with the adoptively transferred form of the disease [15,31].
Positive_regulation (inducible) of PGIA in joints associated with severe combined immunodeficiency, disease and arthritis
2) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.76 Pain Relevance 0.52
Moreover, green fluorescent neutrophil granulocytes were easily detected in the ankles of EGFP-LysM KI BALB/c mice upon induction of PGIA (Figure S1b in Additional file 1).
Positive_regulation (induction) of PGIA in granulocytes associated with arthritis
3) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.59 Pain Relevance 0.12
Furthermore, incidence and severity of antigen-induced arthritis was considerably reduced in RelB-deficient bone marrow chimeric mice compared with control mice [92].
Positive_regulation (induced) of arthritis in bone marrow associated with arthritis
4) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.46 Pain Relevance 0.22
Experiments that have induced arthritis in osteoclast-free models, such as c-fos knockout mice [7] or mice deficient in either rankl or rank, have shown that osteoclasts are essential for joint destruction [8,9].
Positive_regulation (induced) of arthritis in joint associated with targeted disruption and arthritis
5) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 1.35 Pain Relevance 0.51
Since osteoclasts are found in the synovial membrane of all relevant RA animal models, such as collagen-induced arthritis, adjuvant-induced arthritis, the serum transfer model of arthritis as well as mice transgenic for human TNF, the effects of targeting these cells using genetic as well as pharmacological approaches have been intensively studied during the past years.
Positive_regulation (induced) of arthritis in osteoclasts associated with targeted disruption, rheumatoid arthritis and arthritis
6) Confidence 0.00 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 1.14 Pain Relevance 0.45

General Comments

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