INT207384

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 18.55
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
joints 4
T cells 4
osteoclasts 2
granulocytes 1
ankle joints 1
Pgia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 1221 100.00 Very High Very High Very High
rheumatoid arthritis 393 99.28 Very High Very High Very High
Multiple sclerosis 117 99.16 Very High Very High Very High
imagery 260 98.72 Very High Very High Very High
Inflammation 372 97.42 Very High Very High Very High
Central nervous system 26 94.20 High High
chemokine 13 79.44 Quite High
cytokine 36 79.04 Quite High
agonist 13 71.36 Quite High
anesthesia 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 1533 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 728 99.84 Very High Very High Very High
Targeted Disruption 30 99.32 Very High Very High Very High
Rheumatoid Arthritis 393 99.28 Very High Very High Very High
Multiple Sclerosis 156 99.16 Very High Very High Very High
Synovitis 15 97.52 Very High Very High Very High
INFLAMMATION 351 97.42 Very High Very High Very High
Alagille Syndrome 13 96.60 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 26 96.52 Very High Very High Very High
Pressure And Volume Under Development 91 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In adoptively transferred PGIA, we found that FTY720 treatment of SCID mice, transferred with arthritic donor lymphocytes, effectively reduced T-cell presence in both the circulation and synovial fluid but did not inhibit or delay the transfer of arthritis.
Gene_expression (transferred) of PGIA in T-cell associated with severe combined immunodeficiency and arthritis
1) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.69 Pain Relevance 0.48
As we demonstrate in this study, it is easy to identify Gr-1hi cells, in contrast to T cells, in both synovial tissue and fluid samples of inflamed ankle joints of SCID mice with adoptively transferred PGIA.
Gene_expression (transferred) of PGIA in T cells associated with severe combined immunodeficiency and arthritis
2) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.62 Pain Relevance 0.52
However, in the adoptively transferred model of PGIA, we could hardly detect any T cells within the synovial tissue of the joints of SCID mice by TPM imaging either before or after arthritis development.
Gene_expression (transferred) of PGIA in T cells associated with severe combined immunodeficiency, imagery and arthritis
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.36 Pain Relevance 0.59
Moreover, green fluorescent neutrophil granulocytes were easily detected in the ankles of EGFP-LysM KI BALB/c mice upon induction of PGIA (Figure S1b in Additional file 1).
Gene_expression (induction) of PGIA in granulocytes associated with arthritis
4) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.59 Pain Relevance 0.12
In vivo and ex vivo imaging methods reveal poor T-cell migration into the joints during the adoptive transfer of PGIA to SCID mice
Gene_expression (transfer) of PGIA in joints associated with severe combined immunodeficiency, imagery and arthritis
5) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.48 Pain Relevance 0.13
Although neither immune serum nor T cells or B cells (from arthritic animals) appear to be capable of transferring PGIA to SCID mice when injected alone [12,13], mild and transient synovitis is observed after co-injection of immune serum and T cells (but not B cells), and this mild inflammation can even be extended by repeated administration of immune serum ([27] and our unpublished data).
Gene_expression (transferring) of PGIA in T cells associated with inflammation, synovitis, severe combined immunodeficiency and arthritis
6) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.16 Pain Relevance 0.33
Cell depletion experiments indicate that neutrophils are directly involved in the local inflammatory and destructive processes as anti-Gr-1 mAb-mediated elimination of circulating neutrophils promptly abrogates arthritis in both PGIA [49] and a serum/Ab transfer-induced model of RA [47].
Gene_expression (transfer) of PGIA in neutrophils associated with inflammation, rheumatoid arthritis and arthritis
7) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.50 Pain Relevance 0.48
This is a distinct possibility as Wang and colleagues [40] could identify numerous CD4+ cells in the inflamed joint tissue of CIA rats by IHC, whereas we could detect essentially none in adoptively transferred PGIA by means of a similar method.
Neg (none) Gene_expression (transferred) of PGIA in joint associated with arthritis
8) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.53 Pain Relevance 0.66
Both CIA and PGIA can be adoptively transferred to syngeneic immunocompromised mice by lymphocytes isolated from arthritic donors [11-13].
Gene_expression (transferred) of PGIA in lymphocytes associated with arthritis
9) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.64 Pain Relevance 0.71
First, using in vivo two-photon microscopy (TPM), we monitored the migration of fluorescence-labeled T cells into the ankle joints and joint-draining lymph nodes (JDLNs) of syngeneic severe combined immunodeficient (SCID) mice during the course of the adoptive transfer of PGIA.
Gene_expression (transfer) of PGIA in joint associated with severe combined immunodeficiency and arthritis
10) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.44 Pain Relevance 0.61
To this end, we chose to administer oral treatment with the S1P receptor modulator FTY720 [20] to the SCID mice during the adoptive transfer of PGIA.
Gene_expression (transfer) of PGIA associated with severe combined immunodeficiency and arthritis
11) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.80 Pain Relevance 0.26
Therefore, the initial aim of this study was to monitor the migration of fluorescence-labeled 'arthritogenic' T cells into the joints of mice during the adoptive transfer of PGIA, employing in vivo deep-tissue imaging with TPM, used for the first time in an autoimmune model of RA.
Gene_expression (transfer) of PGIA in joints associated with rheumatoid arthritis, imagery and arthritis
12) Confidence 0.11 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.00 Pain Relevance 0.46
First, using in vivo two-photon microscopy (TPM), we monitored the migration of fluorescence-labeled T cells into the ankle joints and joint-draining lymph nodes (JDLNs) of syngeneic severe combined immunodeficient (SCID) mice during the course of the adoptive transfer of PGIA.
Gene_expression (transfer) of PGIA in ankle joints associated with severe combined immunodeficiency and arthritis
13) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 1.44 Pain Relevance 0.61
Since osteoclasts are found in the synovial membrane of all relevant RA animal models, such as collagen-induced arthritis, adjuvant-induced arthritis, the serum transfer model of arthritis as well as mice transgenic for human TNF, the effects of targeting these cells using genetic as well as pharmacological approaches have been intensively studied during the past years.
Gene_expression (transfer) of arthritis in osteoclasts associated with targeted disruption, rheumatoid arthritis and arthritis
14) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 1.15 Pain Relevance 0.45
Since osteoclasts are found in the synovial membrane of all relevant RA animal models, such as collagen-induced arthritis, adjuvant-induced arthritis, the serum transfer model of arthritis as well as mice transgenic for human TNF, the effects of targeting these cells using genetic as well as pharmacological approaches have been intensively studied during the past years.
Gene_expression (transfer) of arthritis in osteoclasts associated with targeted disruption, rheumatoid arthritis and arthritis
15) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 1.15 Pain Relevance 0.45

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