INT207385

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Context Info
Confidence 0.19
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.80
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcr) signal transduction (Calcr) plasma membrane (Calcr)
signal transducer activity (Calcr)
Anatomy Link Frequency
osteoclasts 3
heart 1
Calcr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 98 98.40 Very High Very High Very High
rheumatoid arthritis 102 76.80 Quite High
Arthritis 57 56.56 Quite High
chemokine 2 34.72 Quite Low
cytokine 37 34.24 Quite Low
metalloproteinase 11 5.00 Very Low Very Low Very Low
abatacept 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 88 98.40 Very High Very High Very High
Rheumatoid Arthritis 102 76.80 Quite High
Shock 2 64.08 Quite High
Breast Cancer 3 61.00 Quite High
Injury 11 59.96 Quite High
Multiple Myeloma 3 58.56 Quite High
Malignant Neoplastic Disease 3 57.24 Quite High
Arthritis 57 56.56 Quite High
Cancer 11 56.00 Quite High
Metastasis 3 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the calcitonin receptor was thus only found at sites where the inflammatory synovial tissue was in direct contact with the bone surface, suggesting that final differentiation to osteoclasts depends on direct contact with mineralized tissue.
Gene_expression (Expression) of calcitonin receptor in osteoclasts associated with inflammation
1) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.87 Pain Relevance 0.30
Importantly, multinucleated cells in the synovial tissue express the calcitonin receptor, which is specific to osteoclasts and only expressed in later stages of osteoclast differentiation.
Gene_expression (express) of calcitonin receptor in osteoclasts
2) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.91 Pain Relevance 0.31
Importantly, multinucleated cells in the synovial tissue express the calcitonin receptor, which is specific to osteoclasts and only expressed in later stages of osteoclast differentiation.
Gene_expression (expressed) of calcitonin receptor in osteoclasts
3) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.91 Pain Relevance 0.31
Very little is currently known about the expression and function of NLR, CLR, and RLR in the heart, and thus this review will summarize some of the budding knowledge of TLR below.
Gene_expression (expression) of CLR in heart
4) Confidence 0.15 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.12 Pain Relevance 0

General Comments

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