INT207391

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a, Tnfsf11) extracellular region (Il17a, Tnfsf11) cell differentiation (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
macrophages 2
Il17a (Mus musculus)
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 59 100.00 Very High Very High Very High
cytokine 28 98.80 Very High Very High Very High
Inflammation 48 98.40 Very High Very High Very High
Arthritis 37 95.36 Very High Very High Very High
Inflammatory stimuli 2 65.60 Quite High
antagonist 3 62.00 Quite High
metalloproteinase 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 59 100.00 Very High Very High Very High
INFLAMMATION 43 98.40 Very High Very High Very High
Arthritis 42 95.36 Very High Very High Very High
Seronegative Spondarthritis 2 92.64 High High
Necrosis 3 86.00 High High
Cancer 4 85.64 High High
Disease 13 47.84 Quite Low
Synovitis 6 34.48 Quite Low
Death 1 31.20 Quite Low
Pressure And Volume Under Development 5 16.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, IL-1, IL-6 and IL-17, which are abundant in the synovial membrane of RA patients and increase RANKL expression.
IL-17 Positive_regulation (increase) of Gene_expression (expression) of RANKL associated with rheumatoid arthritis
1) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.95 Pain Relevance 0.51
IL-17A induces RANKL expression by synovial fibro-blasts and osteoblasts to indirectly drive bone erosion [60] and to activate synovial macrophages to secrete the known osteoclastogenic factors TNF and IL-1?
IL-17A Positive_regulation (induces) of Gene_expression (expression) of RANKL in macrophages
2) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.25 Pain Relevance 0.26

General Comments

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