INT2074

Context Info Confidence 0.58 First Reported 1977 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.44 Pain Relevance 1.68

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)

Anatomy Link Frequency neurons 2 red blood cells 1 pyramidal layer 1 CA1 (Homo sapiens)

Pain Link Frequency Relevance Heat long-term potentiation 22 100.00 ischemia 25 99.40 aspirin 2 97.88 cINOD 8 97.70 Sumatriptan 2 96.28 spinal inflammation 86 96.04 Glutamate 34 91.24 Hippocampus 16 87.96 Substantia nigra 24 79.32 Arthritis 1 78.40

Disease Link Frequency Relevance Heat Altitude Sickness 65 99.84 Cv Unclassified Under Development 22 99.40 Stress 289 98.64 Uveitis 3 98.20 Schizophrenia 7 98.04 INFLAMMATION 32 97.58 Low Back Pain 85 96.04 Disease 93 92.76 Hypercalcemia 11 92.16 Experimental Arthritis 1 78.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Within the drugs studied the non steroidal anti-inflammatory drugs (aspirin, keptoprofen, indometacin, phenylbutazone, sodium salicylate and niflumic acid) are the only group which inhibits the enzyme ALA dehydratase.

Negative_regulation (inhibits) of ALA dehydratase associated with aspirin, inflammation and cinod

1) Confidence 0.58 Published 1977 Journal Pathol. Biol. Section Abstract Doc Link 339166 Disease Relevance 0.17 Pain Relevance 0.32

Acetazolamide, inhibitor of CA1, is often used for the medical treatment of uveitis [27].

Negative_regulation (inhibitor) of CA1 associated with uveitis

2) Confidence 0.56 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.89 Pain Relevance 0.58

There were significant decreases in the density of [(3)H]ketanserin binding to the 5-HT(2A) receptor (5-HT(2A)R) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as well as methiothepin-insensitive [(3)H]sumatriptan binding to the 5-HT(1F)R in the CA 1 (p=0.016), stratum radiatum/lacunosum moleculare (p=0.04) and subiculum (p=0.015) from subjects with schizophrenia.

Negative_regulation (decreases) of CA 1 in pyramidal layer associated with sumatriptan and schizophrenia

3) Confidence 0.42 Published 2004 Journal Schizophr. Res. Section Abstract Doc Link 15474910 Disease Relevance 0.58 Pain Relevance 0.19

This selective dysfunction of CA1 astrocytes has been suggested as being important in determining the selective loss of CA1 neurons under ischemia and other OS-related adverse conditions (Ouyang et al., 2007).

Spec (determining) Negative_regulation (loss) of CA1 in neurons associated with stress and ischemia

4) Confidence 0.35 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.71 Pain Relevance 0.33

For example, CA1 neurons, but not CA3 neurons, require superoxide for LTP, and the use of scavengers of superoxide leads to impaired LTP in CA1 but not in CA3 (Klann, 1998; Thiels et al., 2000; Knapp and Klann, 2002; Huddleston et al., 2008).

Negative_regulation (impaired) of CA1 in neurons associated with long-term potentiation

5) Confidence 0.25 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.13 Pain Relevance 0.24

Metabolism of dorzolamide produces N-desthyl which also binds to red blood cells to inhibit carbonic anhydrase I to a greater extent than carbonic anhydrase II.

Negative_regulation (inhibit) of anhydrase I in red blood cells

6) Confidence 0.05 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693974 Disease Relevance 0.51 Pain Relevance 0.03

A carbonic anyhydrase inhibitor, the drug slows the hydration of carbon dioxide:

Negative_regulation (inhibitor) of carbonic anyhydrase

7) Confidence 0.01 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 0.45 Pain Relevance 0

General Comments

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