INT207421

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.62
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GPT) small molecule metabolic process (GPT) biosynthetic process (GPT)
cellular nitrogen compound metabolic process (GPT) cytoplasm (GPT)
Anatomy Link Frequency
kidney 5
liver 3
hepatocytes 2
GPT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 52 99.70 Very High Very High Very High
abdominal pain 1 97.48 Very High Very High Very High
opiate 1 90.96 High High
methadone 1 90.60 High High
cocaine 1 90.16 High High
alcohol 3 88.00 High High
antagonist 18 83.52 Quite High
Inflammation 46 74.12 Quite High
Arthritis 44 50.00 Quite Low
Acupuncture 1 47.36 Quite Low
Disease Link Frequency Relevance Heat
Fever 16 100.00 Very High Very High Very High
Jaundice 5 100.00 Very High Very High Very High
Hepatotoxicity 10 99.54 Very High Very High Very High
Rhabdomyolysis 12 97.76 Very High Very High Very High
Abdominal Pain 1 97.48 Very High Very High Very High
Communicable Diseases 1 96.04 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 44 95.08 Very High Very High Very High
Recurrence 3 93.92 High High
Obesity 73 92.92 High High
Disorder Of Lipid Metabolism 40 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abnormal levels of liver enzymes (lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and ?
Positive_regulation (aspartate aminotransferase) of Gene_expression (aspartate aminotransferase) of alanine aminotransferase in liver
1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860069 Disease Relevance 0.07 Pain Relevance 0
Also an increased in his aminotranferases enzymes was observed Alanine Aminotranseferase (ALT) 555, and Apartate Aminotransferase (ALT) 2292.
Positive_regulation (observed) of Gene_expression (observed) of ALT
2) Confidence 0.49 Published 2008 Journal Cases J Section Body Doc Link PMC2561012 Disease Relevance 0.36 Pain Relevance 0.30
Inclusion criteria were age above 18 years, symptoms (fever or jaundice) lasting less than 21 days, and elevated serum alanine aminotransferase (ALT) ?
Positive_regulation (elevated) of Gene_expression (age) of alanine aminotransferase associated with jaundice and fever
3) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605267 Disease Relevance 0.98 Pain Relevance 0
The principal problem with bosentan is hepatotoxicity initially manifest as elevated levels of alanine aminotransferase and aspartate aminotransferase.
Positive_regulation (elevated) of Gene_expression (levels) of alanine aminotransferase associated with hepatotoxicity
4) Confidence 0.49 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.35 Pain Relevance 0.17
Sixteen patients had elevated levels of aspartate aminotransferase or alanine aminotransferase.
Positive_regulation (elevated) of Gene_expression (levels) of alanine aminotransferase
5) Confidence 0.49 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844980 Disease Relevance 1.46 Pain Relevance 0.17
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Positive_regulation (respectively) of Gene_expression (reflect) of alanine aminotransferase in kidney
6) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.86 Pain Relevance 0
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Positive_regulation (/) of Gene_expression (/) of alanine aminotransferase in kidney
7) Confidence 0.49 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.42 Pain Relevance 0
Plasma aspartate aminotransferase (AST)/alanine aminotransferase (ALT) and BUN were evaluated to reflect liver and kidney function, respectively; none of these parameters were affected by OA-NO2 treatment (AST: 156.8 ± 18.4 versus 159 ± 7.7?
Positive_regulation (respectively) of in liver Gene_expression (reflect) of alanine aminotransferase in kidney
8) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.86 Pain Relevance 0
agonists were shown to increase expression of Gpt in human hepatocytes and HepG2 cells, which occurred via direct regulation of the gene promoter [161, 246].
Positive_regulation (increase) of Gene_expression (expression) of Gpt in hepatocytes associated with agonist
9) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.27 Pain Relevance 0.18

General Comments

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