INT207426

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 12.02
Pain Relevance 3.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL10A1)
Anatomy Link Frequency
chondrocyte 7
cartilage 6
hypertrophic chondrocytes 3
cleavage 2
scleral cells 1
COL10A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 137 99.80 Very High Very High Very High
Osteoarthritis 1188 99.52 Very High Very High Very High
cytokine 106 99.12 Very High Very High Very High
Inflammation 152 90.96 High High
nociceptor 5 77.68 Quite High
Pain 56 73.04 Quite High
COX2 5 71.84 Quite High
cINOD 9 71.12 Quite High
Kinase C 3 68.32 Quite High
COX-2 inhibitor 9 68.16 Quite High
Disease Link Frequency Relevance Heat
Hypertrophy 182 100.00 Very High Very High Very High
Osteoarthritis 1285 99.52 Very High Very High Very High
Focal Cartilage Defect 10 93.52 High High
Adhesions 16 91.68 High High
Disease 103 91.44 High High
INFLAMMATION 163 90.96 High High
Peripheral Arterial Disease 114 89.12 High High
Arthritis 59 88.88 High High
Apoptosis 179 88.64 High High
Injury 75 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chondrocyte hypertrophy, defined by the presence of COL10A1 expression, is a recognized component of the pathology involving excessive collagen cleavage.
Gene_expression (expression) of COL10A1 in cleavage associated with hypertrophy
1) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.61 Pain Relevance 0.12
This involves phenotypic hypertrophy-related changes in chondrocytes, such as the production of type X collagen (COL10A1) (hypertrophy marker), and the upregulation of collagenase matrix metalloproteinase (MMP)-13, as is seen in the fetal growth plate [1-3].
Gene_expression (production) of COL10A1 in growth plate associated with hypertrophy and metalloproteinase
2) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.90 Pain Relevance 0.59
, and COL10A1 expression.
Gene_expression (expression) of COL10A1
3) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.69 Pain Relevance 0.42
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-?

Gene_expression (expression) of COL10A1 in cleavage associated with hypertrophy and osteoarthritis
4) Confidence 0.50 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206385 Disease Relevance 0.87 Pain Relevance 0.04
In comparison with controls, OA explants from five patients cultured in the presence of 10 pg/ml PGE2 showed decreased expression of the genes related to chondrocyte hypertrophy, namely those encoding COL10A1 and MMP-13 (Figure 3).
Gene_expression (expression) of COL10A1 in chondrocyte associated with hypertrophy, metalloproteinase and osteoarthritis
5) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.51 Pain Relevance 0.41
Col10a seemed to be less expressed in both intermediate and fused vertebrae, as also observed from the down-regulated transcription of this gene from the qPCR results.
Gene_expression (expressed) of Col10a in vertebrae
6) Confidence 0.35 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0 Pain Relevance 0
Four genes were down-regulated in both groups, including genes involved in bone (col1a1) and hypertrophic cartilage ECM production (col10a1) and mineralization (osteocalcin and alp).
Gene_expression (production) of col10a1 in cartilage
7) Confidence 0.30 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.05 Pain Relevance 0
The expression of cartilage-associated genes, such as Indian hedge hog, type X collagen, and MMP13, was up-regulated within 3 weeks in vitro.
Gene_expression (expression) of type X collagen in cartilage
8) Confidence 0.15 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2579486 Disease Relevance 0.34 Pain Relevance 0.03
The chondrocytes used in this study strongly expressed type II collagen and aggrecan, which is the common phenotype expressed by proliferating chondrocytes and hypertrophic chondrocytes; whereas the expression of type X collagen, which is the phenotype expressed by hypertrophic chondrocytes, was very low in the cells (data not shown).
Gene_expression (expressed) of type X collagen in chondrocytes
9) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.30 Pain Relevance 0.23
In addition, the expression of type X collagen in the same chondrocytes increased gradually from day 14 of culture without IL-1?
Gene_expression (expression) of type X collagen in chondrocytes
10) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
The chondrocytes used in this study strongly expressed type II collagen and aggrecan, which is the common phenotype expressed by proliferating chondrocytes and hypertrophic chondrocytes; whereas the expression of type X collagen, which is the phenotype expressed by hypertrophic chondrocytes, was very low in the cells (data not shown).
Gene_expression (expression) of type X collagen in hypertrophic chondrocytes
11) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.29 Pain Relevance 0.23
Type X collagen was expressed in ipsilateral cartilage as early as 8 weeks and continued to be expressed through to 20 weeks (Figure 9c).
Gene_expression (expressed) of Type X collagen in cartilage
12) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.11 Pain Relevance 0.03
Immunohistochemistry was used to assess the spatial and temporal expression of MMP-13, alkaline phosphatase, and type X collagen over time (Figure 9).
Gene_expression (expression) of type X collagen
13) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.37 Pain Relevance 0.14
Type X collagen was expressed in ipsilateral cartilage as early as 8 weeks and continued to be expressed through to 20 weeks (Figure 9c).
Gene_expression (expressed) of Type X collagen in cartilage
14) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.11 Pain Relevance 0.03
We investigated this hypothesis in our OA model by analyzing the expression of hypertrophic chondrocyte markers, including MMP-13, alkaline phosphatase, and type X collagen.
Spec (analyzing) Gene_expression (expression) of type X collagen in hypertrophic chondrocyte associated with osteoarthritis
15) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.89 Pain Relevance 0.25
We also saw induction of type X collagen and MMP-13 expression in contralateral cartilage late in the 5-month time course.
Gene_expression (expression) of type X collagen in cartilage
16) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 1.00 Pain Relevance 0.50
In addition, MPC expression of gene markers for chondrocyte hypertrophy and osteogenesis, type X collagen and the key transcription factor for bone formation, RUNX2, were markedly downregulated by PPS at concentrations that induced the strongest MPC chondrogenic differentiation.
Gene_expression (expression) of type X collagen in chondrocyte associated with hypertrophy
17) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.10 Pain Relevance 0
In this context, it should be noted that the chondrogenic differentiation of MPCs mediated by PPS was demonstrated without the addition of growth factors or other chondroinductive supplements and failed to upregulate type I collagen and collagen type X expression.
Gene_expression (expression) of collagen type X
18) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
After in vitro chondrogenesis of scleral cells, COL10A, SOX5, IHH, and MMP13 mRNA expressions increased.
Gene_expression (expressions) of COL10A in scleral cells
19) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2579486 Disease Relevance 0.09 Pain Relevance 0
superfamily reveal a significant level of chondrocyte hypertrophy, indicated by high levels of collagen type X expression.
Gene_expression (expression) of collagen type X in chondrocyte associated with hypertrophy
20) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.70 Pain Relevance 0.08

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