INT207427

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL10A1)
Anatomy Link Frequency
chondrocyte 2
osteoblast 1
cartilage 1
COL10A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 89.96 High High
Osteoarthritis 177 86.64 High High
metalloproteinase 24 37.72 Quite Low
Inflammation 10 26.16 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 32 99.96 Very High Very High Very High
Osteoarthritis 191 99.24 Very High Very High Very High
Osteoporosis 17 98.42 Very High Very High Very High
Calcification 4 98.32 Very High Very High Very High
Stress 2 86.00 High High
Injury 6 75.64 Quite High
Obesity 3 47.52 Quite Low
Anxiety Disorder 1 46.52 Quite Low
Osteophyte 10 26.40 Quite Low
INFLAMMATION 9 26.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-?

Negative_regulation (decrease) of COL10A1 in chondrocyte associated with hypertrophy and osteoarthritis
1) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206385 Disease Relevance 0.87 Pain Relevance 0.04
At fused stage, early markers for osteoblasts and chondrocytes (runx2, osterix, sox9 and bmp2) were upregulated whereas the osteoblast inhibitor (twist) and genes involved in chondrocyte hypertrophy (bmp4, mef2c, col10a, shh and ihh) were downregulated, results also supported by ISH.
Negative_regulation (downregulated) of col10a in osteoblast associated with hypertrophy and osteoporosis
2) Confidence 0.22 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.45 Pain Relevance 0
MMP-13, when activated, will digest the territorial matrix, and deposition of type X collagen and secretion of factors that facilitate calcification of the cartilage matrix (such as alkaline phosphatase) are deleterious to articular cartilage.
Negative_regulation (deposition) of type X collagen in cartilage associated with calcification
3) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 0.69 Pain Relevance 0.18
The gene marker of chondrocyte hypertrophy, collagen type X, was suppressed in the 10-day MMC by PPS at concentrations of 0.1, 0.5 and 2.5 ?
Negative_regulation (suppressed) of collagen type X in chondrocyte associated with hypertrophy
4) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.10 Pain Relevance 0

General Comments

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