INT207429

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.16
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL10A1)
Anatomy Link Frequency
chondrocytes 4
cartilage 2
stem cells 2
growth plate 2
COL10A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 31 99.08 Very High Very High Very High
Osteoarthritis 237 95.76 Very High Very High Very High
Inflammation 46 91.92 High High
nociceptor 1 81.20 Quite High
Pain 23 76.56 Quite High
cINOD 3 74.64 Quite High
COX-2 inhibitor 3 71.68 Quite High
fibrosis 3 60.00 Quite High
cytokine 28 44.80 Quite Low
rheumatoid arthritis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 39 100.00 Very High Very High Very High
Osteoarthritis 264 95.76 Very High Very High Very High
Arthritis 14 92.40 High High
Peripheral Arterial Disease 104 89.72 High High
INFLAMMATION 51 87.48 High High
Pain 24 76.56 Quite High
Osteophyte 11 74.40 Quite High
Apoptosis 62 60.48 Quite High
Fibrosis 4 60.00 Quite High
Stress 15 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This involves phenotypic hypertrophy-related changes in chondrocytes, such as the production of type X collagen (COL10A1) (hypertrophy marker), and the upregulation of collagenase matrix metalloproteinase (MMP)-13, as is seen in the fetal growth plate [1-3].
Positive_regulation (upregulation) of Gene_expression (production) of COL10A1 in growth plate associated with hypertrophy and metalloproteinase
1) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.92 Pain Relevance 0.61
In addition, the expression of type X collagen in the same chondrocytes increased gradually from day 14 of culture without IL-1?
Positive_regulation (increased) of Gene_expression (expression) of type X collagen in chondrocytes
2) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
We also saw induction of type X collagen and MMP-13 expression in contralateral cartilage late in the 5-month time course.
Positive_regulation (induction) of Gene_expression (expression) of type X collagen in cartilage
3) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860072 Disease Relevance 1.00 Pain Relevance 0.50
In this context, it should be noted that the chondrogenic differentiation of MPCs mediated by PPS was demonstrated without the addition of growth factors or other chondroinductive supplements and failed to upregulate type I collagen and collagen type X expression.
Neg (failed) Positive_regulation (upregulate) of Gene_expression (expression) of collagen type X
4) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
superfamily reveal a significant level of chondrocyte hypertrophy, indicated by high levels of collagen type X expression.
Positive_regulation (levels) of Gene_expression (expression) of collagen type X in chondrocyte associated with hypertrophy
5) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.70 Pain Relevance 0.08
It was not surprising to see increased gene expression for collagen type X in chondrogenic culture as the presence of TGF-?
Positive_regulation (increased) of Gene_expression (expression) of collagen type X
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.60 Pain Relevance 0
in cell culture media has previously been associated with increased collagen type X expression in mesenchymal stem cells [45].
Positive_regulation (increased) of Gene_expression (expression) of collagen type X in stem cells
7) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.56 Pain Relevance 0
NO donors increased alkaline phosphatase activity, and transfection of the endothelial NOS isoform increased collagen type X expression.
Positive_regulation (increased) of Gene_expression (expression) of collagen type X
8) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.37 Pain Relevance 0.16

General Comments

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