INT20743

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 12.30
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ltc4s) nuclear envelope (Ltc4s) lyase activity (Ltc4s)
endoplasmic reticulum (Ltc4s) nucleus (Ltc4s)
Anatomy Link Frequency
eosinophils 11
mast cells 3
choroid plexus 2
Ltc4s (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 379 99.38 Very High Very High Very High
Inflammation 34 93.04 High High
corticosteroid 42 91.52 High High
cINOD 60 83.84 Quite High
antagonist 24 83.36 Quite High
COX-2 inhibitor 19 80.48 Quite High
Analgesic 23 75.00 Quite High
Central nervous system 1 75.00 Quite High
dexamethasone 1 71.44 Quite High
Paracetamol 9 59.20 Quite High
Disease Link Frequency Relevance Heat
Polyps 9 99.84 Very High Very High Very High
Occupational Lung Diseases 12 99.78 Very High Very High Very High
Asthma 600 99.36 Very High Very High Very High
Nasal Polyps 73 97.04 Very High Very High Very High
Recurrence 6 96.72 Very High Very High Very High
INFLAMMATION 51 93.04 High High
Rhinitis 38 92.52 High High
Hypersensitivity 21 90.72 High High
Mucositis 3 89.68 High High
Disease 46 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTC4 synthase is overexpressed in bronchi and its mRNA is upregulated in peripheral blood eosinophils.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LTC4 in eosinophils
1) Confidence 0.60 Published 2002 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 14561202 Disease Relevance 1.25 Pain Relevance 0.35
LTC4 synthase, the terminal enzyme for cys-LT production, is markedly overexpressed in eosinophils and mast cells from bronchial biopsy specimens of most patients with AIA.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LTC4 synthase in mast cells associated with asthma
2) Confidence 0.38 Published 1999 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 10400832 Disease Relevance 1.33 Pain Relevance 0.66
These results are consistent with previous in vitro observations that [3H]LTC4 is transferred from CSF into blood by an efficient transport system for LTC4 in choroid plexus.
Positive_regulation (transferred) of Gene_expression (transferred) of LTC4 in choroid plexus
3) Confidence 0.30 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 3081687 Disease Relevance 0 Pain Relevance 0.10
The key enzyme, LTC4 synthase, is overexpressed in bronchi and its mRNA is upregulated in peripheral blood eosinophils.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of LTC4 in eosinophils
4) Confidence 0.29 Published 2001 Journal Curr Opin Allergy Clin Immunol Section Abstract Doc Link 11964666 Disease Relevance 1.00 Pain Relevance 0.42
Exposure of labeled RPC to the calcium ionophore A23187 induced production of [3H]-leukotriene C4, D4 and E4 (LTC4, LTD4 and LTE4) and [3H]-prostaglandins (PGs).
Positive_regulation (induced) of Gene_expression (production) of LTC4
5) Confidence 0.20 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6316436 Disease Relevance 0 Pain Relevance 0
In an examination of 27 patients by Kaplan et al. [33] patients with sinonasal polyps were noted by radioimmunoassay to have elevated levels of LTC4.
Positive_regulation (elevated) of Gene_expression (levels) of LTC4 associated with polyps
6) Confidence 0.18 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2292155 Disease Relevance 1.50 Pain Relevance 0.12
LTC4 synthase, the terminal enzyme for cys-LT production, is markedly overexpressed in eosinophils and mast cells from bronchial biopsy specimens of most patients with AIA.
Positive_regulation (overexpressed) of in eosinophils Gene_expression (overexpressed) of LTC4 synthase in mast cells associated with asthma
7) Confidence 0.13 Published 1999 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 10400832 Disease Relevance 1.33 Pain Relevance 0.66
These investigators found that fivefold higher eosinophil counts accounted for the increased LTC4 synthase expression in polyps from AEA[53].
Positive_regulation (accounted) of Gene_expression (expression) of LTC4 synthase in eosinophil associated with asthma and polyps
8) Confidence 0.09 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.99 Pain Relevance 0.04
CONCLUSION: We conclude that sevoflurane increases pulmonary LTC4, NO3-, and NO2- production in pigs, indicating an inflammatory response.


Positive_regulation (increases) of Gene_expression (production) of LTC4
9) Confidence 0.08 Published 2004 Journal Acta Anaesthesiol Scand Section Body Doc Link 14674972 Disease Relevance 0 Pain Relevance 0
In these cells LTC4 synthase alternatively converts LTC4 from LTA4.
Positive_regulation (converts) of Gene_expression (converts) of LTC4
10) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.56 Pain Relevance 0.06
In these cells LTC4 synthase alternatively converts LTC4 from LTA4.
Positive_regulation (converts) of Gene_expression (converts) of LTC4 synthase
11) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.56 Pain Relevance 0.06
The key enzyme, leukotriene C4 synthase, is overexpressed in bronchi, and its messenger RNA is upregulated in peripheral blood eosinophils.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of leukotriene C4 synthase in eosinophils
12) Confidence 0.06 Published 2002 Journal Am J Ther Section Abstract Doc Link 11941383 Disease Relevance 1.45 Pain Relevance 0.60
The concentration of LTC4 which produced an increase in Isc of 4 mu Eq/h.cm2 was 181 nM in the absence of SK&F 104353 and this value did not differ significantly from the value of 212 nM in the presence of SK&F 104353 (0.1 microM).
Positive_regulation (increase) of Gene_expression (produced) of LTC4
13) Confidence 0.06 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2156177 Disease Relevance 0 Pain Relevance 0.04
These investigators found that fivefold higher eosinophil counts accounted for the increased LTC4 synthase expression in polyps from AEA[53].
Positive_regulation (increased) of Gene_expression (expression) of LTC4 synthase in eosinophil associated with asthma and polyps
14) Confidence 0.06 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.98 Pain Relevance 0.04
Although COX expression does not consistently distinguish aspirin-sensitive from aspirin-tolerant asthmatics, a marked increase in expression of leukotriene C4 (LTC4) synthase in aspirin-sensitive asthmatics has been demonstrated [4].
Positive_regulation (increase) of Gene_expression (expression) of leukotriene C4 associated with aspirin and occupational lung diseases
15) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154436 Disease Relevance 1.35 Pain Relevance 0.65
LTD4, LTC4 and LTE4 (respective ED50 of 0.21 +/- .1, 0.64 +/- .2 and 2.0 +/- .1 microgram kg-1) produced dose-dependent increases in insufflation pressure when given as a bolus injection to anesthetized guinea pigs (Konzett-Rössler).
Positive_regulation (increases) of Gene_expression (produced) of LTC4
16) Confidence 0.02 Published 1985 Journal Prostaglandins Section Abstract Doc Link 3925502 Disease Relevance 0 Pain Relevance 0.04

General Comments

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