INT207446

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Context Info
Confidence 0.73
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.38
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (OLR1) extracellular region (OLR1) cell adhesion (OLR1)
plasma membrane (OLR1)
Anatomy Link Frequency
foam cell 2
neck 1
OLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 43 97.84 Very High Very High Very High
rheumatoid arthritis 138 91.96 High High
Osteoarthritis 50 78.56 Quite High
methotrexate 8 62.40 Quite High
cytokine 8 59.76 Quite High
imagery 47 58.12 Quite High
corticosteroid 10 46.84 Quite Low
Pain 34 35.04 Quite Low
Pain score 12 12.68 Low Low
Infliximab 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 97.84 Very High Very High Very High
Cancer 90 95.52 Very High Very High Very High
Atherosclerosis 13 95.44 Very High Very High Very High
Disorder Of Lipid Metabolism 113 94.76 High High
Diabetes Mellitus 64 92.40 High High
Rheumatoid Arthritis 140 91.96 High High
Stress 7 91.92 High High
Body Weight 2 85.84 High High
Cardiovascular Disease 20 84.68 Quite High
Adhesions 8 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pCAG-loxP-stop-loxP cassette was then subcloned to the 5?
Localization (cassette) of lox
1) Confidence 0.73 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.15 Pain Relevance 0.03
Rac1 flox/flox and Rac1 flox/flox PDGFB-iCreER mice were implanted subcutaneously with tamoxifen (Rac1 flox/flox and Rac1 flox/flox PDGFB-iCreER) or placebo (Rac1 flox/flox PDGFB-iCreER) 1 mg-slow release pellets in the scruff of the neck.
Localization (release) of lox in neck
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0
Measurement of autoantibody titers against oxidized low-density lipoprotein
Localization (Measurement) of oxidized low-density lipoprotein
3) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860077 Disease Relevance 0.37 Pain Relevance 0.14
ROS can stimulate oxidation of LDL, forming ox-LDL, which is not recognized by the LDL receptor leading to foam cell formation[8].
Localization (oxidation) of ox-LDL in foam cell
4) Confidence 0.10 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.70 Pain Relevance 0
Ox-LDL leads to phospholipid release, activating endothelial cells, thereby initiating an inflammatory process which leads to the formation of foam cells and subsequent fatty streaks.
Localization (release) of Ox-LDL in foam cells associated with inflammation
5) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350142 Disease Relevance 1.44 Pain Relevance 0.24
Interestingly, Aflapin® shows more capability to reduce ICAM-1 secretion than that of 5-Loxin®.


Localization (secretion) of 5-Loxin
6) Confidence 0.03 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.44 Pain Relevance 0.17

General Comments

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