INT207466

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (LGALS3, ADAMTS5) proteinaceous extracellular matrix (LGALS3, ADAMTS5) cell differentiation (LGALS3)
peptidase activity (ADAMTS5) mRNA processing (LGALS3) plasma membrane (LGALS3)
Anatomy Link Frequency
chondrocytes 3
cartilage 1
LGALS3 (Homo sapiens)
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 30 99.80 Very High Very High Very High
Osteoarthritis 60 99.72 Very High Very High Very High
Inflammation 22 65.44 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 66 99.72 Very High Very High Very High
Pressure And Volume Under Development 22 93.88 High High
INFLAMMATION 18 65.44 Quite High
Osteoporosis 12 62.80 Quite High
Hyperplasia 2 61.12 Quite High
Arthritis 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Synovitis 4 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings were confirmed by the experiments in which we demonstrated in human OA chondrocytes that gal-3 stimulated the expression of ADAMTS-5 and MMP-3, the main enzymes involved in proteoglycan degradation in cartilage.
gal-3 Positive_regulation (stimulated) of in cartilage Gene_expression (expression) of ADAMTS-5 in chondrocytes associated with metalloproteinase and osteoarthritis
1) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.48 Pain Relevance 0.21
Data show that human OA chondrocytes incubated with rh-gal-3 for 24 h increased ADAMTS-5 expression in a biphasic mode.
rh-gal-3 Positive_regulation (incubated) of Gene_expression (expression) of ADAMTS-5 in chondrocytes associated with osteoarthritis
2) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.40 Pain Relevance 0.30

General Comments

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