INT207474

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.79
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAMTS5) extracellular region (ADAMTS5) proteinaceous extracellular matrix (ADAMTS5)
Anatomy Link Frequency
tendon 1
cartilage 1
ADAMTS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 54 99.76 Very High Very High Very High
cytokine 37 89.12 High High
Pain 44 61.68 Quite High
Mechanotransduction 3 55.08 Quite High
Inflammation 22 52.64 Quite High
Osteoarthritis 60 51.12 Quite High
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 96.80 Very High Very High Very High
Tendinopathy 30 86.12 High High
Pressure And Volume Under Development 22 70.88 Quite High
Osteoporosis 12 60.80 Quite High
Hyperplasia 2 54.76 Quite High
INFLAMMATION 18 52.64 Quite High
Osteoarthritis 66 51.12 Quite High
Rupture 12 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Independent regulation of the ADAMTS aggrecanase genes has been noted in several tissues (Flannery et al., 2000; Bau et al., 2002; Pratta et al., 2003; Kevorkian et al., 2004; Moulharat et al., 2004; Wachsmuth et al., 2004; Cross et al., 2005).
Neg (Independent) Regulation (regulation) of ADAMTS aggrecanase
1) Confidence 0.20 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.09 Pain Relevance 0.08
The regulation of ADAMTS-5 is crucial since it was recently demonstrated by two independent groups (using knock-out mouse models) that ADAMTS-5 is the major aggrecanase responsible for proteoglycan degradation in cartilage destruction [41,42].
Regulation (regulation) of ADAMTS-5 in cartilage associated with targeted disruption
2) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.22 Pain Relevance 0.18
Studies using explant and cell cultures from other tissues have shown increased aggrecanase activity under conditions where ADAMTS mRNA and/or protein levels are not altered (Caterson et al., 2000; Flannery et al., 2000; Yaminishi et al., 2002; Pratta et al., 2003; Patwari et al., 2005), indicating that both the translation of the mRNA and the processing of the ADAMTS proenzymes are subject to regulation.
Neg (not) Regulation (altered) of aggrecanase
3) Confidence 0.09 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.06 Pain Relevance 0.12
are potentially important factors controlling ADAMTS aggrecanase activities in tendon pathology.



Regulation (controlling) of ADAMTS aggrecanase in tendon
4) Confidence 0.08 Published 2008 Journal Matrix Biol Section Abstract Doc Link PMC2443387 Disease Relevance 0.11 Pain Relevance 0.16
We show that ADAMTS-5 was more sensitive than MMP-3 to gal-3, since its expression was stimulated with very low concentrations of gal-3, unlike MMP-3, which required higher concentrations for stimulation.
Regulation (sensitive) of ADAMTS-5 associated with metalloproteinase
5) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.31 Pain Relevance 0.24

General Comments

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