INT207496

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.10
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
plasma 2
peripheral nerve 2
epithelium 2
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 588 91.12 High High
Inflammation 14 63.24 Quite High
cytokine 2 45.44 Quite Low
dorsal root ganglion 9 37.80 Quite Low
tetrodotoxin 36 31.80 Quite Low
Nav1.9 2 15.64 Low Low
Nav1.1 4 15.36 Low Low
unmyelinated 26 5.00 Very Low Very Low Very Low
addiction 21 5.00 Very Low Very Low Very Low
Pyramidal cell 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 95.84 Very High Very High Very High
Colitis 31 91.68 High High
Congenital Anomalies 4 83.60 Quite High
INFLAMMATION 13 63.24 Quite High
Diarrhoea 7 60.08 Quite High
Syndrome 8 56.24 Quite High
Inflammatory Bowel Disease 17 51.96 Quite High
Recurrence 2 50.84 Quite High
Targeted Disruption 13 50.00 Quite Low
Ganglion Cysts 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiments using CHO and 1610 cell lines have demonstrated a 2- to 4-fold greater Na+ channel expression when ?
Regulation (fold) of Gene_expression (expression) of Na
1) Confidence 0.04 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.32 Pain Relevance 0
-subunits have been shown to regulate the expression density of the Na+ channel in the plasma membrane.
Regulation (regulate) of Gene_expression (expression) of Na in plasma
2) Confidence 0.04 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.26 Pain Relevance 0
Another important observation, producing even more significant effect on basal Na+ entry, is the shift of the inactivation threshold by ?
Regulation (effect) of Gene_expression (entry) of Na
3) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
To evaluate secretory and absorptive function of the colonic epithelium, we measured the basal and forskolin-stimulated Isc (which is an assessment of the electrogenic anion secretion, and its stimulation by an increase in intracellular cAMP levels), as well as net Na+ absorption before and after an increase in cAMP levels.
Regulation (assessment) of Gene_expression (absorption) of Na in epithelium
4) Confidence 0.03 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.52 Pain Relevance 0.06
On the other hand, activation of PKC has regulatory effects on skeletal muscle Na+ channels [25], brain Na+ channels [26] and peripheral nerve Na+ channel expressed in Xenopus oocytes [27].
Regulation (effects) of Gene_expression (expressed) of Na in peripheral nerve
5) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.06
m (single channel conductance of known (axonal) voltage-gated Na and K channels: average ?
Regulation (voltage) of Gene_expression (channels) of Na
6) Confidence 0.03 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.22
Na channel densities above 2–4 ?
Regulation (densities) of Gene_expression (channel) of Na
7) Confidence 0.03 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.33
m (single channel conductance of known (axonal) voltage-gated Na and K channels: average ?
Regulation (gated) of Gene_expression (channels) of Na
8) Confidence 0.03 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1864994 Disease Relevance 0 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox