INT2075

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Context Info
Confidence 0.67
First Reported 1977
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.48
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
T cells 2
blood 1
microglial cells 1
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 231 100.00 Very High Very High Very High
cINOD 8 99.84 Very High Very High Very High
Inflammatory response 10 99.38 Very High Very High Very High
antagonist 49 99.02 Very High Very High Very High
Inflammation 192 97.96 Very High Very High Very High
Cannabinoid 7 95.76 Very High Very High Very High
Cannabinoid receptor 10 80.72 Quite High
aspirin 2 80.28 Quite High
Endocannabinoid 12 79.20 Quite High
Inflammatory mediators 5 75.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 211 99.72 Very High Very High Very High
Aging 1 95.44 Very High Very High Very High
Cancer 25 94.96 High High
Apoptosis 17 93.64 High High
Asthma 324 91.68 High High
Shock 8 89.40 High High
Nicotine Addiction 1 73.36 Quite High
Eosinophilia 22 65.76 Quite High
Necrosis 12 63.40 Quite High
Adenocarcinoma 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Influence of metals and non-steroid anti-inflammatory drugs on the activity of human red cell ALA dehydratase "in vitro" (author's transl)].
Transcription (activity) of red associated with inflammation and cinod
1) Confidence 0.67 Published 1977 Journal Pathol. Biol. Section Title Doc Link 339166 Disease Relevance 0.18 Pain Relevance 0.29
The response to the high frequency sound was suppressed by the presence of the low frequency sound (Fig. 4D; red versus black curve; p<10?
Transcription (presence) of red
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861002 Disease Relevance 0 Pain Relevance 0
The panel will include immunophenotypings, detection of cytokine mRNA in lymphocytes, determination of cytokine patterns in peripheral blood, cellular cytotoxicity assays against autologous tumor cells and determination of apoptotic effects of interferon against autologous tumor cells.


Transcription (detection) of cytokine in blood associated with cancer, apoptosis and cytokine
3) Confidence 0.03 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1087479 Disease Relevance 0.34 Pain Relevance 0.10
To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.
Transcription (transcription) of cytokine associated with cytokine
4) Confidence 0.01 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.42 Pain Relevance 0.30
For instance, AEA suppresses LPS-induced nitric oxide production by mouse peritoneal macrophages [11], and LPS-induced cytokine mRNA expression in rat microglial cells [12].
Transcription (expression) of cytokine in microglial cells associated with cytokine
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.23 Pain Relevance 0.18
Furthermore, aminophylline decreases Th2-related cytokine mRNA expression but increases Th1-related cytokines mRNA expression [35].


Transcription (expression) of cytokine associated with cytokine
6) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.66 Pain Relevance 0.37
Reverse transcription-PCR analyses revealed that the intracisternal A-particle element was transcribed as a part of the CXBK MOR-1 mRNA.
Transcription (transcribed) of A-particle element
7) Confidence 0.01 Published 2006 Journal Pharmacogenet. Genomics Section Body Doc Link 16708053 Disease Relevance 0 Pain Relevance 0
Regulation of cytokine gene transcription
Transcription (transcription) of cytokine associated with cytokine
8) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.16 Pain Relevance 0.25
Studies of the role of CREB in T cells have provided conflicting results with regard to whether CREB is a positive or negative regulator of cytokine transcription.
Transcription (transcription) of cytokine in T cells associated with cytokine
9) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.07 Pain Relevance 0.08
Another mechanism by which p38 MAPK may modulate cytokine gene transcription in T cells may be through the regulation of gene accessibility.
Transcription (transcription) of cytokine in T cells associated with cytokine
10) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.06 Pain Relevance 0.21
The CB(2) antagonist, however, when administered alone augmented the production of cytokine mRNAs.
Transcription (production) of cytokine associated with antagonist and cytokine
11) Confidence 0.00 Published 2000 Journal Glia Section Abstract Doc Link 10594923 Disease Relevance 0 Pain Relevance 0.70
HSF1 also plays a role in the acute inflammatory response in the negative regulation of cytokine gene transcription.
Transcription (transcription) of cytokine gene associated with inflammatory response and cytokine
12) Confidence 0.00 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16278218 Disease Relevance 0.37 Pain Relevance 0.14

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