INT207521

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Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.89
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tfap2a) Golgi apparatus (Tfap2a) nucleus (Tfap2a)
DNA binding (Tfap2a) transcription factor binding (Tfap2a) cytoplasm (Tfap2a)
Anatomy Link Frequency
embryos 1
adipocyte 1
Tfap2a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 47 98.56 Very High Very High Very High
Potency 4 98.54 Very High Very High Very High
mu opioid receptor 84 98.16 Very High Very High Very High
Inflammation 68 96.20 Very High Very High Very High
antagonist 5 93.52 High High
opioid receptor 6 89.48 High High
qutenza 5 85.28 High High
Glutamate receptor 6 75.84 Quite High
Cannabinoid 46 65.76 Quite High
opiate 1 62.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 65 97.84 Very High Very High Very High
Apoptosis 38 96.48 Very High Very High Very High
INFLAMMATION 86 96.20 Very High Very High Very High
Obesity 236 93.52 High High
Cleft Palate 8 91.48 High High
Insulin Resistance 12 87.96 High High
Hypercholesterolemia 2 80.40 Quite High
Diabetes Mellitus 17 78.08 Quite High
Sprains And Strains 4 63.76 Quite High
Cancer 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the domains of expression of several key transcription factors important to normal craniofacial and cardiac development including AP2, Msx2, Dlx5, and Dlx6 were reduced in Spry1;Wnt1-Cre transgenic embryos.


Gene_expression (expression) of AP2 in embryos associated with targeted disruption
1) Confidence 0.48 Published 2010 Journal BMC Dev Biol Section Abstract Doc Link PMC2874773 Disease Relevance 0.29 Pain Relevance 0
Our laboratory and others have demonstrated that MOR promoter activity is regulated by many enhancer elements and their related transcriptional factors such as SOX, SP1, AP2, NF-?
Gene_expression (factors) of AP2 associated with mu opioid receptor
2) Confidence 0.30 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.06 Pain Relevance 0.54
-mediated adipogenesis and fail to express adipogenic markers like aP2.
Gene_expression (express) of aP2
3) Confidence 0.19 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.29 Pain Relevance 0
Primers/probe ABI identifiers for mouse studies were Tusc5 (Mm00624784_m1), aP2/FABP4 (Mm00445880_m1), PPAR?
Gene_expression (/) of aP2
4) Confidence 0.13 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.07 Pain Relevance 0
transcriptional potency in 3T3L1 cells, forced 3T3L1 adipocyte differentiation, and induced the expression of adipocyte differentiation marker aP2.
Gene_expression (expression) of aP2 in adipocyte associated with potency
5) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.14 Pain Relevance 0.29
, it not only enhances the expressions of adiponectin and aP2 but also inhibits the TNF-?
Gene_expression (expressions) of aP2
6) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 1.05 Pain Relevance 0.54
The GABAA receptor contains several AP-2 binding motifs.
Gene_expression (contains) of AP-2
7) Confidence 0.05 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.08

General Comments

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