INT207548

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.46
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
U (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 252 100.00 Very High Very High Very High
Opioid 6 99.40 Very High Very High Very High
antagonist 3 85.12 High High
opioid receptor 15 5.00 Very Low Very Low Very Low
Morphine 6 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
Endogenous opioid 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 24 97.80 Very High Very High Very High
Contagious Ecthyma 42 61.24 Quite High
Neuroblastoma 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, these three uAUGs could synergistically repress the downstream of MOR gene expression.


uAUGs Negative_regulation (repress) of Gene_expression (expression) of MOR gene associated with mu opioid receptor
1) Confidence 0.01 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.16 Pain Relevance 0.49
In conclusion, we provide evidence that mouse MOR expression is inhibited at the translational level by the presence of uORFs.
uORFs Negative_regulation (inhibited) of Gene_expression (expression) of MOR associated with mu opioid receptor
2) Confidence 0.01 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.14 Pain Relevance 0.27
Because mouse uORFs could repress downstream MOR gene expression, we performed opioid radioligand binding assays (Figure 3C).
uORFs Negative_regulation (repress) of Gene_expression (expression) of MOR gene associated with mu opioid receptor and opioid
3) Confidence 0.01 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.16 Pain Relevance 0.50

General Comments

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