INT207565

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.83
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LIPG) extracellular space (LIPG) extracellular region (LIPG)
lipid metabolic process (LIPG)
Anatomy Link Frequency
plasma 2
visceral 1
adipose tissue 1
cornea 1
adipocytes 1
LIPG (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 1 97.84 Very High Very High Very High
cytokine 20 96.52 Very High Very High Very High
Inflammation 103 96.12 Very High Very High Very High
rheumatoid arthritis 19 93.92 High High
alcohol 2 89.84 High High
cINOD 80 83.76 Quite High
Inflammatory marker 3 69.68 Quite High
Serotonin 8 66.80 Quite High
Bioavailability 18 57.12 Quite High
tolerance 26 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type I 1 100.00 Very High Very High Very High
Hyperlipidemia 12 99.54 Very High Very High Very High
Obesity 437 99.44 Very High Very High Very High
Abdominal Obesity 19 97.44 Very High Very High Very High
Cardiovascular Disease 62 97.40 Very High Very High Very High
Reprotox - General 1 34 97.22 Very High Very High Very High
INFLAMMATION 112 96.12 Very High Very High Very High
Diabetes Mellitus 210 95.60 Very High Very High Very High
Insulin Resistance 67 95.08 Very High Very High Very High
Apoptosis 4 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect can be explained by the action of testosterone in inhibiting lipoprotein lipase and thereby reducing triglyceride uptake into adipocytes (Sorva et al 1988), an action which seems to occur preferentially in visceral fat (Marin et al 1995; Marin et al 1996).
Negative_regulation (inhibiting) of lipoprotein lipase in visceral associated with obesity
1) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.12 Pain Relevance 0
The well-established lipolytic effect of GH has been attributed to suppression of lipoprotein lipase activity or enhanced responsiveness of adipocytes to catecholamine [20,32–34].
Negative_regulation (suppression) of lipoprotein lipase in adipocytes associated with catecholamine and obesity
2) Confidence 0.07 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865086 Disease Relevance 0.46 Pain Relevance 0.05
can reduce fat depot size by several means: by increasing lipolysis and decreasing lipoprotein lipase activity, by decreasing lipogenic enzymes, by down-regulating the adipogenic differentiation factors, and by increasing adipose tissue apoptosis [45].
Negative_regulation (decreasing) of lipoprotein lipase in adipose tissue associated with obesity and apoptosis
3) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.81 Pain Relevance 0.32
Tyloxapol also has been shown to inhibit lipoprotein lipase; however the long-term toxicologic effects of tyloxapol on the cornea at the concentration used in nepafenac ophthalmic solution is unknown (Bhatia and Wade 1991).
Negative_regulation (inhibit) of lipoprotein lipase in cornea
4) Confidence 0.05 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.83 Pain Relevance 0.22
Testosterone reduces lipoprotein lipase activity and increases lipolysis in males, but in females these effects are counteracted by estrogen [71].
Negative_regulation (reduces) of lipoprotein lipase
5) Confidence 0.04 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.91 Pain Relevance 0.09
Fenofibrate increases the lipolyses and the elimination of TH-rich particles from the plasma by activating the lipoprotein lipase and reducing the production of apoprotein C-III, which is an inhibitor of the lipoprotein lipase activity.
Negative_regulation (inhibitor) of lipoprotein lipase in plasma
6) Confidence 0.03 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626933 Disease Relevance 0.53 Pain Relevance 0.03
In addition, two large phase III trials for prostate cancer using AAV are underway, and orphan drug status has been granted recently by the European Union for AAV-mediated gene therapy for familial lipoprotein lipase deficiency.
Negative_regulation (deficiency) of lipoprotein lipase associated with hyperlipoproteinemia type i and reprotox - general 1
7) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.88 Pain Relevance 0.05
The increased influx of NEFAs to the liver promotes TG synthesis and the assembly and secretion of large VLDL; this results in elevated plasma VLDL levels (hypertriglyceridemia) and postprandial hyperlipidemia that is compounded by impaired lipoprotein lipase activity - the latter regarded as independently associated with coronary artery disease.
Negative_regulation (impaired) of lipoprotein lipase in plasma associated with cardiovascular disease and hyperlipidemia
8) Confidence 0.00 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3022752 Disease Relevance 1.10 Pain Relevance 0

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