INT207570

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 61
Disease Relevance 33.27
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
adipocytes 6
hepatocytes 3
skeletal muscle 3
muscle 1
blood 1
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 364 99.66 Very High Very High Very High
Inflammation 501 97.92 Very High Very High Very High
withdrawal 18 76.76 Quite High
Inflammatory response 20 76.72 Quite High
rheumatoid arthritis 11 71.12 Quite High
Catecholamine 3 67.24 Quite High
Kinase C 24 60.52 Quite High
tolerance 109 50.00 Quite Low
fibrosis 19 42.40 Quite Low
antagonist 16 27.08 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 760 99.92 Very High Very High Very High
Obesity 412 99.60 Very High Very High Very High
Metabolic Syndrome 1582 99.44 Very High Very High Very High
Diabetes Mellitus 1002 98.00 Very High Very High Very High
INFLAMMATION 562 97.92 Very High Very High Very High
Stress 279 96.82 Very High Very High Very High
Apoptosis 301 96.76 Very High Very High Very High
Hyperinsulinism 116 93.84 High High
Necrosis 64 93.36 High High
Cancer 96 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the feedback signals do generate an overshoot in IRS1 phosphorylation.
Phosphorylation (phosphorylation) of IRS1
1) Confidence 0.71 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
The resulting signals are therefore proportional to the relative degree of phosphorylation of IR and IRS1.
Phosphorylation (phosphorylation) of IRS1
2) Confidence 0.71 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.15 Pain Relevance 0
To gain further insight into which mechanisms that are most active during the early events of insulin signaling, we have measured the transient phosphorylation of IR and IRS1 during the first ten minutes after a step increase in extracellular insulin concentration.
Phosphorylation (phosphorylation) of IRS1
3) Confidence 0.71 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.11 Pain Relevance 0
The first part reports a rapid overshoot in IR and IRS1 phosphorylation upon insulin stimulation of human fat cells.
Phosphorylation (phosphorylation) of IRS1 in fat cells associated with obesity
4) Confidence 0.71 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.10 Pain Relevance 0
Thus autophosphorylated, the IR is active against a set of intracellular signal mediator proteins, in particular the insulin receptor substrate-1 (IRS1), which becomes phosphorylated on tyrosine residues.
Phosphorylation (phosphorylated) of IRS1
5) Confidence 0.71 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.38 Pain Relevance 0
We measured phosphorylated and total IR and IRS1 by SDS-PAGE and immunoblotting.
Phosphorylation (phosphorylated) of IRS1
6) Confidence 0.62 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.17 Pain Relevance 0
To achieve a robust measurement signal, the extent of phosphorylation of both IR and IRS1 were divided by total amount of IR and IRS1, respectively.
Phosphorylation (phosphorylation) of IRS1
7) Confidence 0.62 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.16 Pain Relevance 0
Thus autophosphorylated, the IR is active against a set of intracellular signal mediator proteins, in particular the insulin receptor substrate-1 (IRS1), which becomes phosphorylated on tyrosine residues.
Phosphorylation (phosphorylated) of substrate-1
8) Confidence 0.62 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.39 Pain Relevance 0
Indeed, cytokines such as TNF alpha - which are high in MetS-patient blood cause serine phosphorylation of IRS-1 and inhibit its tyrosine phosphorylation with consequent impairment of mTOR function [16].
Phosphorylation (phosphorylation) of IRS-1 in blood associated with metabolic syndrome and cytokine
9) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.79 Pain Relevance 0.18
receptor sub-units and tyrosine phosphorylation of IRS-1 after their recruitment to the cell membrane.
Phosphorylation (phosphorylation) of IRS-1
10) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.54 Pain Relevance 0.03
In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1).
Phosphorylation (phosphorylation) of IRS-1
11) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.73 Pain Relevance 0.04
In this study, the authors showed that leptin increases serine-138 phosphorylation of insulin receptor substrates-1 (IRS-1).
Phosphorylation (phosphorylation) of insulin receptor substrates-1
12) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.73 Pain Relevance 0.04
The main cellular molecular mechanism of insulin desensitization, with consequent insulin resistance presents in MetS-patients, involves increased serine phosphorylation and decreased tyrosine phosphorylation of IRS-1.
Phosphorylation (phosphorylation) of IRS-1 associated with metabolic syndrome and insulin resistance
13) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.72 Pain Relevance 0
The main cellular molecular mechanism of insulin desensitization, with consequent insulin resistance presents in MetS-patients, involves increased serine phosphorylation and decreased tyrosine phosphorylation of IRS-1.
Phosphorylation (phosphorylation) of IRS-1 associated with metabolic syndrome and insulin resistance
14) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.72 Pain Relevance 0
Indeed, recent data has shown that the cytokine leptin promotes phosphorylation of serine 318 in IRS-1 in both skeletal muscle and in lymphocytes of obese and diabetic hyperleptinemic patients [10].
Phosphorylation (phosphorylation) of IRS-1 in lymphocytes associated with diabetes mellitus, obesity and cytokine
15) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.91 Pain Relevance 0.14
Phosphorylation of the tyrosine residues 608 on IRS-1 after insulin stimulation is necessary for propagation of the signal with consequent active-mTOR expression.
Phosphorylation (Phosphorylation) of IRS-1
16) Confidence 0.60 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.70 Pain Relevance 0.06
We examined the extent of phosphorylation of IR and IRS1 on tyrosine residues in human adipocytes.
Phosphorylation (phosphorylation) of IRS1 in adipocytes associated with obesity
17) Confidence 0.55 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0.20 Pain Relevance 0
Ability of S6K1 to promote serine phosphorylation of IRS-1 has been suggested as a potential mechanism of insulin resistance [30-37,53,54].
Phosphorylation (phosphorylation) of IRS-1 associated with insulin resistance
18) Confidence 0.55 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.24 Pain Relevance 0
In this study, both overfeeding diets induced significant increases in phosphorylation of mTOR and S6K1, yet only HF overfeeding was associated with increased serine phosphorylation of IRS-1.
Phosphorylation (phosphorylation) of IRS-1
19) Confidence 0.55 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.17 Pain Relevance 0
We measured time-courses in primary human adipocytes for the short-term phosphorylation dynamics of the insulin receptor (IR) and the IR substrate-1 in response to a step increase in insulin concentration.
Phosphorylation (phosphorylation) of substrate-1 in adipocytes associated with obesity
20) Confidence 0.48 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2424138 Disease Relevance 0.27 Pain Relevance 0

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