INT207614

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.16
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Hspd1) cytosol (Hspd1) mitochondrion (Hspd1)
extracellular space (Hspd1) Golgi apparatus (Hspd1) cytoplasm (Hspd1)
Hspd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 34 97.36 Very High Very High Very High
Inflammation 141 97.00 Very High Very High Very High
monoamine 2 80.28 Quite High
Inflammatory response 11 80.16 Quite High
Kinase C 21 70.40 Quite High
Inflammatory mediators 2 56.40 Quite High
metalloproteinase 2 54.40 Quite High
chemokine 2 49.84 Quite Low
agonist 4 23.16 Low Low
rheumatoid arthritis 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 10 100.00 Very High Very High Very High
Adhesions 4 99.44 Very High Very High Very High
Apoptosis 12 97.96 Very High Very High Very High
INFLAMMATION 141 97.00 Very High Very High Very High
Injury 33 82.64 Quite High
Infection 52 81.12 Quite High
Viral Infection 2 61.64 Quite High
Necrosis 6 58.96 Quite High
Neuroblastoma 3 50.00 Quite Low
Syndrome 2 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, only HSP60 was able to stimulate the production of IFN?
HSP60 Binding (Indeed) of
1) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.35 Pain Relevance 0.23
Further studies showed that HSP60 and Gp96 can tightly bind to LPS in a saturable manner and enhance its biological activity, as well as that of the TLR2 ligand Pam3Cys [43–45].
HSP60 Binding (bind) of
2) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.36 Pain Relevance 0.13
It is worthy of note that some up-regulated proteins in our ICAT result list, such as HSP60, T-complex protein 1, heterogeneous nuclear ribonucleoprotein U and aspartate aminotransferase are related to DNA binding, protein folding, mitochondrion and regulation of apoptosis.
HSP60 Binding (binding) of associated with apoptosis
3) Confidence 0.12 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.19 Pain Relevance 0.14
Listeria adhesion protein (LAP) was shown to bind to the host cell heat-shock protein 60 [39] and a specific fibronectin-binding protein (FbpA) of L. monocytogenes was identified to interact with cell surface fibronectin in the murine model [40].
heat-shock protein 60 Binding (bind) of associated with shock and adhesions
4) Confidence 0.02 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.25 Pain Relevance 0

General Comments

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