INT207643

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca, Mapk1) protein complex (Prkca, Mapk1) cytoplasm (Prkca, Mapk1)
cytosol (Prkca, Mapk1) nucleus (Prkca, Mapk1) kinase activity (Prkca, Mapk1)
Prkca (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 42 100.00 Very High Very High Very High
Hippocampus 10 24.56 Low Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 10 86.20 High High
Neuroblastoma 6 50.00 Quite Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low
Starvation 4 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A PKC specific inhibitor GF102903X was able to totally abolish the ERK phosphorylation by PMA, indicating that PMA activates ERK through PKC.
PKC Positive_regulation (activates) of ERK associated with kinase c
1) Confidence 0.09 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.08 Pain Relevance 0.13
PKC stimulation activates ERK through several pathways, including Ras-dependent and –independent mechanisms, that are not well understood 48.
PKC Positive_regulation (activates) of ERK associated with kinase c
2) Confidence 0.08 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.09 Pain Relevance 0.24

General Comments

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