INT20765

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Context Info
Confidence 0.34
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.91
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (INHBA) growth (INHBA) extracellular region (INHBA)
cell-cell signaling (INHBA)
Anatomy Link Frequency
arms 1
skin 1
embryonic stem cells 1
neural 1
INHBA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 11 91.68 High High
agonist 11 79.60 Quite High
Morphine 2 79.60 Quite High
opiate 3 78.88 Quite High
Enkephalin 1 77.92 Quite High
metalloproteinase 3 60.76 Quite High
Inflammatory response 1 58.12 Quite High
Osteoarthritis 1 17.76 Low Low
imagery 10 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-eclampsia 100 99.20 Very High Very High Very High
Dermal Scarring 48 98.28 Very High Very High Very High
Keloid Scars 6 97.84 Very High Very High Very High
Neurodegenerative Disease 12 93.24 High High
Disease 44 82.88 Quite High
Injury 4 71.04 Quite High
INFLAMMATION 3 57.72 Quite High
Disorder Of Lipid Metabolism 2 53.08 Quite High
Stress 1 44.84 Quite Low
Insulin Resistance 6 32.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a downregulation of INHBA protein level was observed when comparing keloid margin with external normal skin.7 In addition, Seifert et al7 also noted an increased expression of inhibitor for INHBA at the margin.
Negative_regulation (downregulation) of INHBA in skin associated with dermal scarring
1) Confidence 0.34 Published 2010 Journal Eplasty Section Body Doc Link PMC2851107 Disease Relevance 0.80 Pain Relevance 0.09
The secretagogue effect of activin on irGnRH release from cultured placental cells was increased by the presence of estriol and reduced by the addition of progesterone.
Negative_regulation (reduced) of activin
2) Confidence 0.03 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2156890 Disease Relevance 0 Pain Relevance 0.57
Neural conversion from human embryonic stem cells (hESCs) has been demonstrated in a variety of systems including chemically defined suspension culture, not requiring extrinsic signals, as well as in an adherent culture method that involves dual SMAD inhibition using Noggin and SB431542 (an inhibitor of activin/nodal signaling).
Negative_regulation (inhibitor) of activin in embryonic stem cells
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0
Recent studies suggest that inhibition of both the activin/nodal and BMP arms of the TGF?
Negative_regulation (inhibition) of activin in arms
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0.27 Pain Relevance 0.04
Many studies have been reported using inhibin A and activin A as predictors of preeclampsia.
Negative_regulation (using) of activin associated with pre-eclampsia
5) Confidence 0.00 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 0.68 Pain Relevance 0.03
Activin/Nodal inhibition promotes accelerated and highly efficient neural conversion of hESCs
Negative_regulation (inhibition) of Activin in neural
6) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

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