INT207679

Context Info Confidence 0.25 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.12 Pain Relevance 0.07

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1) endoplasmic reticulum (Bace1) enzyme binding (Bace1)

Anatomy Link Frequency heart 1 Bace1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Serotonin 1 76.24 sodium channel 2 72.16 addiction 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Hypertension 18 65.76 Coronary Heart Disease 3 59.12 Heart Rate Under Development 19 40.48 Sprains And Strains 18 32.64 Disease 6 5.00 Pressure And Volume Under Development 4 5.00 Targeted Disruption 2 5.00 Syncope 1 5.00 Communicable Diseases 1 5.00 Drug Dependence 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ten of the genes investigated (Bace1, Timm8b, Ncam1, Slc37a4, Cul5, Fxyd2, Fxyd6, Ptpn9, Scamp2 and Scamp5) did not display any association with the heart rate trait and were eliminated.

Bace1 Binding (association) of in heart

1) Confidence 0.25 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1865373 Disease Relevance 0.12 Pain Relevance 0.07

General Comments

This test has worked.