INT207726

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.14
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADM) extracellular space (ADM) aging (ADM)
extracellular region (ADM) cell-cell signaling (ADM) cytoplasm (ADM)
Anatomy Link Frequency
spike 1
HGF 1
ADM (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 75 92.16 High High
antagonist 9 77.08 Quite High
Osteoarthritis 27 58.16 Quite High
ischemia 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 55 97.16 Very High Very High Very High
Rheumatoid Arthritis 75 92.16 High High
Adhesions 86 91.60 High High
Metastasis 52 91.04 High High
Disease 7 67.60 Quite High
Osteoarthritis 27 58.16 Quite High
Cancer 39 43.40 Quite Low
Paralysis 6 26.24 Quite Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm further the role for the adrenomedullin receptor and downstream signaling molecules, we used the pharmacologic PKA inhibitor H-89.
Regulation (role) of adrenomedullin
1) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.46 Pain Relevance 0.38
MSMB, CCND1, EFNA3, FKBP and ADM, HGF are similarly regulated in mouse models and in our study [35-37].
Regulation (regulated) of ADM in HGF
2) Confidence 0.15 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.68 Pain Relevance 0.04
This served as a control for the AM condition.
Regulation (control) of AM
3) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0
This revealed that the 37 units fired significantly higher spike rates in the AM condition but only for the duration of the time interval during the passage of the wave-front (Fig. 9D; P < 0.01).
Regulation (fired) of AM in spike
4) Confidence 0.02 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2583157 Disease Relevance 0 Pain Relevance 0

General Comments

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