INT207773

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.85
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRIA1) endoplasmic reticulum (GRIA1) plasma membrane (GRIA1)
Anatomy Link Frequency
prefrontal 1
cerebellum 1
GRIA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 98.40 Very High Very High Very High
Glutamate receptor 29 97.82 Very High Very High Very High
nMDA receptor 85 96.56 Very High Very High Very High
Glutamate 56 66.84 Quite High
Hippocampus 18 64.72 Quite High
agonist 6 49.44 Quite Low
nMDA receptor antagonist 8 28.32 Quite Low
Dopamine 3 14.16 Low Low
amygdala 118 5.00 Very Low Very Low Very Low
long-term potentiation 35 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Phobia 23 92.80 High High
Autism 628 90.80 High High
Aging 2 65.36 Quite High
Disease 4 50.88 Quite High
Attention Deficit Hyperactivity Disorder 22 19.64 Low Low
Influenza Virus Infection 2 16.36 Low Low
Anxiety Disorder 115 5.00 Very Low Very Low Very Low
Cognitive Disorder 97 5.00 Very Low Very Low Very Low
Intellectual Impairment 48 5.00 Very Low Very Low Very Low
Syndrome 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However contrary to the increase at the gene and protein level, determining the density of glutamate receptors by autoradiography in the cerebellum, prefrontal cortex, and caudate putamen revealed a significant density decrease of AMPA receptors in the cerebellum of autistics.
Negative_regulation (decrease) of AMPA in cerebellum associated with glutamate receptor
1) Confidence 0.57 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.35 Pain Relevance 0.37
However contrary to the increase at the gene and protein level, determining the density of glutamate receptors by autoradiography in the cerebellum, prefrontal cortex, and caudate putamen revealed a significant density decrease of AMPA receptors in the cerebellum of autistics.
Negative_regulation (decrease) of AMPA in prefrontal associated with glutamate receptor
2) Confidence 0.19 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC3010743 Disease Relevance 0.35 Pain Relevance 0.37
By contrast, blockade of AMPA and kainate receptors with a selective antagonist such as LY326325 (see Chemical names) disrupts not only encoding but also consolidation and retrieval of spatial memories, showing that fast synaptic transmission via AMPA receptors is required more generally for all of these processes [23].
Negative_regulation (blockade) of AMPA associated with antagonist
3) Confidence 0.01 Published 2006 Journal Trends Pharmacol Sci Section Body Doc Link PMC1867319 Disease Relevance 0.14 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox