INT207779

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.16
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap3d1) transport (Ap3d1) vesicle-mediated transport (Ap3d1)
Golgi apparatus (Ap3d1) cytoplasm (Ap3d1)
Ap3d1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 96.68 Very High Very High Very High
halothane 30 95.28 Very High Very High Very High
isoflurane 2 93.40 High High
Calcium channel 6 48.68 Quite Low
sodium channel 10 44.16 Quite Low
anesthesia 46 19.68 Low Low
Regional anesthesia 2 13.28 Low Low
Serotonin 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
iatrogenic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 338 100.00 Very High Very High Very High
Central Core Disease 44 99.80 Very High Very High Very High
Disseminated Intravascular Coagulation 14 90.36 High High
Renal Failure 4 90.16 High High
Hypertrophic Cardiomyopathy 2 86.96 High High
Syndrome 42 84.40 Quite High
Nemaline Myopathy 2 84.24 Quite High
Recurrence 2 83.76 Quite High
Hypopituitarism 4 79.92 Quite High
Contracture 20 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When suspicion of MH exists, family members should not be given trigger anesthetic agents, i.e. potent volatile anesthetic agents such as halothane, sevoflurane, desflurane, enflurane, isoflurane and succinylcholine, and testing is recommended.
Localization (suspicion) of MH associated with isoflurane, halothane and malignant hyperthermia
1) Confidence 0.11 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.49 Pain Relevance 0.09
In this latter case, the likelihood of an RYR1 mutation resulting in both MH and CCD depends on a number of factors including sensitivity of mutant protein to agonists, size of the intracellular Ca2+ pool and the level of abnormality in channel-gating (reviewed in [19]).
Localization (resulting) of MH associated with agonist, central core disease and malignant hyperthermia
2) Confidence 0.09 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.67 Pain Relevance 0.05

General Comments

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