INT207782

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.53
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CACNA1S) transmembrane transport (CACNA1S) cytoplasm (CACNA1S)
Anatomy Link Frequency
skeletal muscle 1
CACNA1S (Homo sapiens)
Pain Link Frequency Relevance Heat
halothane 15 62.48 Quite High
anesthesia 23 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 169 100.00 Very High Very High Very High
Central Core Disease 22 42.00 Quite Low
Neuromuscular Disease 1 29.28 Quite Low
Syndrome 21 5.00 Very Low Very Low Very Low
Muscle Rigidity 18 5.00 Very Low Very Low Very Low
Fever 16 5.00 Very Low Very Low Very Low
Hyperkalemia 14 5.00 Very Low Very Low Very Low
Rhabdomyolysis 14 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Muscle Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amongst these loci, mutations with a clear association with MH have been identified in only one gene, CACNA1S, encoding the alpha subunit of the dihydropyridine receptor, the voltage sensor of the skeletal muscle calcium release channel [29,42,43].
CACNA1S Spec (clear) Binding (association) of in skeletal muscle associated with malignant hyperthermia
1) Confidence 0.30 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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