INT207784

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ap3d1, CACNA1S) protein transporter activity (Ap3d1) transport (Ap3d1)
vesicle-mediated transport (Ap3d1) Golgi apparatus (Ap3d1) plasma membrane (CACNA1S)
Ap3d1 (Mus musculus)
CACNA1S (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 5 99.22 Very High Very High Very High
halothane 15 83.12 Quite High
Calcium channel 3 45.64 Quite Low
anesthesia 23 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 169 100.00 Very High Very High Very High
Syndrome 21 75.04 Quite High
Congenital Anomalies 3 48.24 Quite Low
Muscle Rigidity 18 15.52 Low Low
Stress 12 9.96 Low Low
Contracture 10 6.40 Low Low
Central Core Disease 22 5.00 Very Low Very Low Very Low
Fever 16 5.00 Very Low Very Low Very Low
Hyperkalemia 14 5.00 Very Low Very Low Very Low
Rhabdomyolysis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At least six other genetic loci have been implicated in MH, including one that elaborates the sodium channel [21,28] although only one other gene, CACNL1A3, encoding the main subunit of the dihydropyrodine receptor (DHPR), have been shown to be altered by an MH-linked mutation [29].
MH Regulation (altered) of CACNL1A3 associated with sodium channel and malignant hyperthermia
1) Confidence 0.05 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.97 Pain Relevance 0.16

General Comments

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