INT207803

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.15
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atm) cell cycle (Atm) DNA binding (Atm)
kinase activity (Atm) cytoplasm (Atm)
Anatomy Link Frequency
poly 1
Atm (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 7 66.60 Quite High
cerebral cortex 12 43.36 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 59 97.08 Very High Very High Very High
Recurrence 21 96.52 Very High Very High Very High
Pulmonary Fibrosis 6 66.60 Quite High
Embryonic Lethality 1 60.80 Quite High
Telangiectasia 22 45.76 Quite Low
Frailty 4 34.40 Quite Low
Aging 13 27.60 Quite Low
Disease 101 5.00 Very Low Very Low Very Low
Targeted Disruption 67 5.00 Very Low Very Low Very Low
Death 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Association of heterozygosity of the ATM gene with adverse side effects of radiotherapy and risk for ipsilateral breast tumour recurrence (IBTR)
Regulation (heterozygosity) of ATM associated with breast cancer and recurrence
1) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1971057 Disease Relevance 1.09 Pain Relevance 0.03
As the substrate peptide is known to be a target for the PI3-kinase family members ATM, ATM related, and DNA–PK (Lees-Miller et al., 1992; Canman et al., 1998; Tibbetts et al., 1999), to demonstrate the specificity of DNA activation of the enzyme activity, the extracts (75 µg protein) were preincubated with active or inactive (heat inactivated at 80°C for 30 min) 0.1% DNase I (Roche) for 2 h at 4°C.
Regulation (target) of ATM
2) Confidence 0.25 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0
PARP-1 interacts with ATM in vivo and ATM is modified by poly(ADP-ribosyl)ation
Regulation (modified) of ATM in poly
3) Confidence 0.23 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.06 Pain Relevance 0
As the substrate peptide is known to be a target for the PI3-kinase family members ATM, ATM related, and DNA–PK (Lees-Miller et al., 1992; Canman et al., 1998; Tibbetts et al., 1999), to demonstrate the specificity of DNA activation of the enzyme activity, the extracts (75 µg protein) were preincubated with active or inactive (heat inactivated at 80°C for 30 min) 0.1% DNase I (Roche) for 2 h at 4°C.
Regulation (target) of ATM
4) Confidence 0.11 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0 Pain Relevance 0

General Comments

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